[HTML][HTML] Ionizing-radiation induced DNA double-strand breaks: a direct and indirect lighting up
The occurrence of DNA double-strand breaks (DSBs) induced by ionizing radiation has
been extensively studied by biochemical or cell imaging techniques. Cell imaging …
been extensively studied by biochemical or cell imaging techniques. Cell imaging …
Golgi structure and function in health, stress, and diseases
The Golgi apparatus is a central intracellular membrane-bound organelle with key functions
in trafficking, processing, and sorting of newly synthesized membrane and secretory proteins …
in trafficking, processing, and sorting of newly synthesized membrane and secretory proteins …
NaLi-H1: A universal synthetic library of humanized nanobodies providing highly functional antibodies and intrabodies
In vitro selection of antibodies allows to obtain highly functional binders, rapidly and at lower
cost. Here, we describe the first fully synthetic phage display library of humanized llama …
cost. Here, we describe the first fully synthetic phage display library of humanized llama …
Aβ-induced Golgi fragmentation in Alzheimer's disease enhances Aβ production
Golgi fragmentation occurs in neurons of patients with Alzheimer's disease (AD), but the
underlying molecular mechanism causing the defects and the subsequent effects on …
underlying molecular mechanism causing the defects and the subsequent effects on …
Knockout of the Golgi stacking proteins GRASP55 and GRASP65 impairs Golgi structure and function
Golgi reassembly stacking protein of 65 kDa (GRASP65) and Golgi reassembly stacking
protein of 55 kDa (GRASP55) were originally identified as Golgi stacking proteins; however …
protein of 55 kDa (GRASP55) were originally identified as Golgi stacking proteins; however …
[HTML][HTML] Golgi structure formation, function, and post-translational modifications in mammalian cells
The Golgi apparatus is a central membrane organelle for trafficking and post-translational
modifications of proteins and lipids in cells. In mammalian cells, it is organized in the form of …
modifications of proteins and lipids in cells. In mammalian cells, it is organized in the form of …
The role of GRASP65 in Golgi cisternal stacking and cell cycle progression
In vitro assays identified the Golgi peripheral protein GRASP65 as a Golgi stacking factor
that links adjacent Golgi cisternae by forming mitotically regulated trans‐oligomers. These …
that links adjacent Golgi cisternae by forming mitotically regulated trans‐oligomers. These …
New insights into the Golgi stacking proteins
The Golgi stacking proteins, GRASP55 and GRASP65, are best known for their roles in
Golgi structure formation. These peripheral Golgi proteins form trans-oligomers that hold the …
Golgi structure formation. These peripheral Golgi proteins form trans-oligomers that hold the …
Nature-inspired design of motif-specific antibody scaffolds
JT Koerber, ND Thomsen, BT Hannigan… - Nature …, 2013 - nature.com
Aberrant changes in post-translational modifications (PTMs) such as phosphate groups
underlie a majority of human diseases. However, detection and quantification of PTMs for …
underlie a majority of human diseases. However, detection and quantification of PTMs for …
GRASP depletion–mediated Golgi destruction decreases cell adhesion and migration via the reduction of α5β1 integrin
The Golgi apparatus is a membrane-bound organelle that serves as the center for trafficking
and processing of proteins and lipids. To perform these functions, the Golgi forms a …
and processing of proteins and lipids. To perform these functions, the Golgi forms a …