The history of the Wnt pathway is an adventure that takes us from mice and flies to frogs,
zebrafish and beyond, sketching the outlines of a molecular signalling cascade along the …

Osteogenesis imperfecta (OI) is a phenotypically and genetically heterogeneous skeletal
dysplasia characterized by bone fragility, growth deficiency, and skeletal deformity …

Newborn mice homozygous for a targeted disruption of insulin-like growth factor gene 1 (Igf-
1) exhibit a growth deficiency similar in severity to that prevlously observed in viable Igf-2 …

The Wnt signalling pathway is an ancient system that has been highly conserved during
evolution. It has a crucial role in the embryonic development of all animal species, in the …

Neural crest cells are multipotential stem cells that contribute extensively to vertebrate
development and give rise to various cell and tissue types. Determination of the fate of …

Osteogenesis imperfecta is a genetic disorder characterized by low bone mass, decreased
bone strength, increased bone fragility, and shortened stature. Autosomal dominant …

Wnt genes and components of Wnt signalling pathways have been implicated in a wide
spectrum of important biological phenomena, ranging from early organismal development to …

ABSTRACT β-Catenin is a central component of both the cadherin-catenin cell adhesion
complex and the Wnt signaling pathway. We have investigated the role of β-catenin during …

Wnt genes comprise a large family of secreted polypeptides that are expressed in spatially
and tissue-restricted patterns during vertebrate embryonic development. Mutational analysis …

Oestrogen produces diverse biological effects through binding to the oestrogen receptor
(ER). The ER is a steroid hormone nuclear receptor, which, when bound to oestrogen …