Determinants, maintenance, and function of organellar pH
SA Freeman, S Grinstein… - Physiological reviews, 2023 - journals.physiology.org
The protonation state of soluble and membrane-associated macromolecules dictates their
charge, conformation, and functional activity. In addition, protons (H+ or their equivalents) …
charge, conformation, and functional activity. In addition, protons (H+ or their equivalents) …
Ratiometric fluorescent probes for pH mapping in cellular organelles
The intracellular pH (pHi) in organelles, including mitochondria, endoplasmic reticulum,
lysosomes, and nuclei, differs from the cytoplasmic pH, and thus maintaining the pH of these …
lysosomes, and nuclei, differs from the cytoplasmic pH, and thus maintaining the pH of these …
The body electric 2.0: recent advances in developmental bioelectricity for regenerative and synthetic bioengineering
Breakthroughs in biomedicine and synthetic bioengineering require predictive, rational
control over anatomical structure and function. Recent successes in manipulating cellular …
control over anatomical structure and function. Recent successes in manipulating cellular …
Vitamin D3 decreases glycolysis and invasiveness, and increases cellular stiffness in breast cancer cells
Breast cancer is one of the major causes of death in the USA. Cancer cells, including breast,
have high glycolysis rates to meet their energy demands for survival and growth. Vitamin D 3 …
have high glycolysis rates to meet their energy demands for survival and growth. Vitamin D 3 …
Aggressive prostate cancer cell nuclei have reduced stiffness
It has been hypothesized that highly metastatic cancer cells have softer nuclei and hence
would travel faster through confining environments. Our goal was to prove this untested …
would travel faster through confining environments. Our goal was to prove this untested …
Higher glucose enhances breast cancer cell aggressiveness
Cancer cells overexpress several transcription factors and motor proteins, such as NFkB and
kinesin, to accommodate their high energy demand as well as migratory needs via …
kinesin, to accommodate their high energy demand as well as migratory needs via …
Myrtenal-induced V-ATPase inhibition-A toxicity mechanism behind tumor cell death and suppressed migration and invasion in melanoma
BX Martins, RF Arruda, GA Costa, H Jerdy… - … et Biophysica Acta (BBA …, 2019 - Elsevier
Background Metastatic tumor cells have acidic extracellular pH and differential
electrochemical H+ gradients generated across their cell membranes by V-type H+ …
electrochemical H+ gradients generated across their cell membranes by V-type H+ …
Potent inhibition of macropinocytosis by niclosamide in cancer cells: a novel mechanism for the anticancer efficacy for the antihelminthic
SR Sennoune, GD Nandagopal, S Ramachandran… - Cancers, 2023 - mdpi.com
Simple Summary Niclosamide, a drug used to treat tapeworm infection, has been shown to
have potential as an anticancer drug. The mechanism proposed for this action is the drug …
have potential as an anticancer drug. The mechanism proposed for this action is the drug …
Soluble adenylyl cyclase is an acid‐base sensor in rainbow trout red blood cells that regulates intracellular pH and haemoglobin–oxygen binding
Aim To identify the physiological role of the acid‐base sensing enzyme, soluble adenylyl
cyclase (sAC), in red blood cells (RBC) of the model teleost fish, rainbow trout. Methods We …
cyclase (sAC), in red blood cells (RBC) of the model teleost fish, rainbow trout. Methods We …
Multi-cancer V-ATPase molecular signatures: A distinctive balance of subunit C isoforms in esophageal carcinoma
J Couto-Vieira, P Nicolau-Neto, EP Costa… - …, 2020 - thelancet.com
Background V-ATPases are hetero-oligomeric enzymes consisting of 13 subunits and
playing key roles in ion homeostasis and signaling. Differential expression of these proton …
playing key roles in ion homeostasis and signaling. Differential expression of these proton …