Allostatic load and its impact on health: a systematic review
J Guidi, M Lucente, N Sonino, GA Fava - Psychotherapy and …, 2020 - karger.com
Introduction: Allostatic load refers to the cumulative burden of chronic stress and life events.
It involves the interaction of different physiological systems at varying degrees of activity …
It involves the interaction of different physiological systems at varying degrees of activity …
Debunking the myth of exercise-induced immune suppression: redefining the impact of exercise on immunological health across the lifespan
JP Campbell, JE Turner - Frontiers in immunology, 2018 - frontiersin.org
Epidemiological evidence indicates that regular physical activity and/or frequent structured
exercise reduces the incidence of many chronic diseases in older age, including …
exercise reduces the incidence of many chronic diseases in older age, including …
The interplay between immunosenescence and age-related diseases
F Barbé-Tuana, G Funchal, CRR Schmitz… - Seminars in …, 2020 - Springer
The aging immune system (immunosenescence) has been implicated with increased
morbidity and mortality in the elderly. Of note, T cell aging and low-grade inflammation …
morbidity and mortality in the elderly. Of note, T cell aging and low-grade inflammation …
Immunosenescence in aging: between immune cells depletion and cytokines up-regulation
MT Ventura, M Casciaro, S Gangemi… - Clinical and Molecular …, 2017 - Springer
Background The immunosenescence is a relatively recent chapter, correlated with the linear
extension of the average life began in the nineteenth century and still in progress. The most …
extension of the average life began in the nineteenth century and still in progress. The most …
Immune resilience despite inflammatory stress promotes longevity and favorable health outcomes including resistance to infection
SK Ahuja, MS Manoharan, GC Lee… - Nature …, 2023 - nature.com
Some people remain healthier throughout life than others but the underlying reasons are
poorly understood. Here we hypothesize this advantage is attributable in part to optimal …
poorly understood. Here we hypothesize this advantage is attributable in part to optimal …
The immune system and its dysregulation with aging
L Müller, S Di Benedetto, G Pawelec - … and cell biology of ageing: Part II …, 2019 - Springer
Aging leads to numerous changes that affect all physiological systems of the body including
the immune system, causing greater susceptibility to infectious disease and contributing to …
the immune system, causing greater susceptibility to infectious disease and contributing to …
Age and immunity: what is “immunosenescence”?
G Pawelec - Experimental gerontology, 2018 - Elsevier
As is apparent from the many contributions to this Special Issue of the Journal, the impact of
age on immunity is nefarious, with all manner of dysregulated responses attributed to …
age on immunity is nefarious, with all manner of dysregulated responses attributed to …
HIV-infected individuals with low CD4/CD8 ratio despite effective antiretroviral therapy exhibit altered T cell subsets, heightened CD8+ T cell activation, and increased …
S Serrano-Villar, T Sainz, SA Lee, PW Hunt… - PLoS …, 2014 - journals.plos.org
A low CD4/CD8 ratio in elderly HIV-uninfected adults is associated with increased morbidity
and mortality. A subset of HIV-infected adults receiving effective antiretroviral therapy (ART) …
and mortality. A subset of HIV-infected adults receiving effective antiretroviral therapy (ART) …
Lipid peroxidation-derived aldehydes, 4-hydroxynonenal and malondialdehyde in aging-related disorders
G Barrera, S Pizzimenti, M Daga, C Dianzani, A Arcaro… - Antioxidants, 2018 - mdpi.com
Among the various mechanisms involved in aging, it was proposed long ago that a
prominent role is played by oxidative stress. A major way by which the latter can provoke …
prominent role is played by oxidative stress. A major way by which the latter can provoke …
Human T cell immunosenescence and inflammation in aging
A Bektas, SH Schurman, R Sen… - Journal of leukocyte …, 2017 - Wiley Online Library
The aging process is driven by a finite number of inter‐related mechanisms that ultimately
lead to the emergence of characteristic phenotypes, including increased susceptibility to …
lead to the emergence of characteristic phenotypes, including increased susceptibility to …