The uptake of calcium into and extrusion of calcium from the mitochondrial matrix is a
fundamental biological process that has critical effects on cellular metabolism, signaling …

The Na+/Ca2+ exchanger, an ion transport protein, is expressed in the plasma membrane
(PM) of virtually all animal cells. It extrudes Ca2+ in parallel with the PM ATP-driven Ca2+ …

Mitochondrial Ca2+ efflux is linked to numerous cellular activities and pathophysiological
processes. Although it is established that an Na+-dependent mechanism mediates …

Extensively revised, the fourth edition of this highly successful book takes into account the
many newly determined protein structures that provide molecular insight into chemiosmotic …

This review provides a selective history of how studies of mitochondrial cation transport (K+,
Na+, Ca2+) developed in relation to the major themes of research in bioenergetics. It then …

Mutations in PINK1 cause autosomal recessive Parkinson's disease. PINK1 is a
mitochondrial kinase of unknown function. We investigated calcium homeostasis and …

Mitochondria are essential for proper cellular function through their critical roles in ATP
synthesis, reactive oxygen species production, calcium (Ca2+) buffering, and apoptotic …

Ca 2+ is a universal carrier of biological information: it controls cell life from its origin at
fertilization to its end in the process of programmed cell death. Ca 2+ is a conventional …

The free Ca2+ concentration within the mitochondrial matrix ([Ca2+] m) regulates the rate of
ATP production and other [Ca2+] m sensitive processes. It is set by the balance between …

Mitochondrial Ca2+ uptake and release play a fundamental role in the control of different
physiological processes, such as cytoplasmic Ca2+ signalling, ATP production and …