Cholesterol, an essential component of the brain, and its local metabolism are involved in
many neurodegenerative diseases. The blood-brain barrier is impermeable to cholesterol; …

Efavirenz (Sustiva®) is a first-generation non-nucleoside reverse transcriptase inhibitor
(NNRTI) used to treat human immunodeficiency virus (HIV) type 1 infection or to prevent the …

Prion diseases are a group of incurable zoonotic neurodegenerative diseases (NDDs) in
humans and other animals caused by the prion proteins. The abnormal folding and …

Currently, no effective therapeutics exist for the treatment of incurable neurodegenerative
diseases such as Alzheimer's disease (AD). The cellular prion protein (PrPC) acts as a high …

Apolipoprotein J (APOJ) is a multifunctional protein with genetic evidence suggesting an
association between APOJ polymorphisms and Alzheimer's disease as well as exfoliation …

Alzheimer's disease (AD) is an incurable, progressive and devastating neurodegenerative
disease. Pathogenesis of AD is associated with the aggregation and accumulation of …

The brain cholesterol content is determined by the balance between the pathways of in situ
biosynthesis and cholesterol elimination via 24-hydroxylation catalyzed by CYP46A1 …

A small dose of the anti-HIV drug efavirenz (EFV) was previously discovered to activate
CYP46A1, a cholesterol-eliminating enzyme in the brain, and mitigate some of the …

The molecular cause of transmissible spongiform encephalopathies (TSEs) involves the
conversion of the cellular prion protein (PrPC) into its pathogenic form, called prion scrapie …

Prions are infectious protein particles known to cause prion diseases. The biochemical entity
of the pathogen is the misfolded prion protein (PrPSc) that forms insoluble amyloids to …