The current development of nanobiotechnologies requires a better understanding of cell–
surface interactions on the nanometre scale. Recently, advances in nanoscale patterning …

Cell mechanical properties, eg elastic and shear modulus, play vital roles in cell activities
and functions, such as cell growth, cell division, cell motion, and cell adhesion …

From the extracellular matrix to the cytoskeleton, a network of molecular links connects cells
to their environment. Molecules in this network transmit and detect mechanical forces, which …

Integrins have emerged as key sensory molecules that translate chemical and physical cues
from the extracellular matrix (ECM) into biochemical signals that regulate cell behavior …

A current medical challenge is the replacement of tissue which can be thought of in terms of
bone tissue engineering approaches. The key problem in bone tissue engineering lies in …

Magnetic micromanipulation using magnetic tweezers is a versatile biophysical technique
and has been used for single-molecule unfolding, rheology measurements, and studies of …

The self-assembly of block copolymers to generate nanopatterns is of great interest as an
inexpensive approach to sub-20 nm lithography. Compared to thermal annealing, solvent …

We have characterized early steps of α2β1 integrin-mediated cell adhesion to a collagen
type I matrix by using single-cell force spectroscopy. In agreement with the role of α2β1 as a …

Substrate topography plays a vital role in cell and tissue structure and function in situ, where
nanometric features, for example, the detail on single collagen fibrils, influence cell …

Cell adhesion to surfaces represents the basis for niche colonization and survival. Here we
establish serial quantification of adhesion forces of different cell types using a single probe …