The trip of the tip: understanding the growth cone machinery
LA Lowery, DV Vactor - Nature reviews Molecular cell biology, 2009 - nature.com
The central component in the road trip of axon guidance is the growth cone, a dynamic
structure that is located at the tip of the growing axon. During its journey, the growth cone …
structure that is located at the tip of the growing axon. During its journey, the growth cone …
[HTML][HTML] Biomechanical microenvironment in peripheral nerve regeneration: from pathophysiological understanding to tissue engineering development
Peripheral nerve injury (PNI) caused by trauma, chronic disease and other factors may lead
to partial or complete loss of sensory, motor and autonomic functions, as well as neuropathic …
to partial or complete loss of sensory, motor and autonomic functions, as well as neuropathic …
An integrated cytoskeletal model of neurite outgrowth
Neurite outgrowth underlies the wiring of the nervous system during development and
regeneration. Despite a significant body of research, the underlying cytoskeletal mechanics …
regeneration. Despite a significant body of research, the underlying cytoskeletal mechanics …
Actin waves: origin of cell polarization and migration?
N Inagaki, H Katsuno - Trends in cell biology, 2017 - cell.com
Actin filaments and associated proteins undergo wave-like movement in various cell types.
Recent studies with cutting-edge analyses, including live-cell imaging, biophysical …
Recent studies with cutting-edge analyses, including live-cell imaging, biophysical …
Integrating chemistry and mechanics: the forces driving axon growth
K Franze - Annual review of cell and developmental biology, 2020 - annualreviews.org
The brain is our most complex organ. During development, neurons extend axons, which
may grow over long distances along well-defined pathways to connect to distant targets. Our …
may grow over long distances along well-defined pathways to connect to distant targets. Our …
[HTML][HTML] Neuronal polarization: From spatiotemporal signaling to cytoskeletal dynamics
M Schelski, F Bradke - Molecular and Cellular Neuroscience, 2017 - Elsevier
Neuronal polarization establishes distinct molecular structures to generate a single axon
and multiple dendrites. Studies over the past years indicate that this efficient separation is …
and multiple dendrites. Studies over the past years indicate that this efficient separation is …
Waves in neural media
PC Bressloff - Lecture notes on mathematical modelling in the life …, 2014 - Springer
This is a book on mathematical neuroscience, in which the unifying theme is wavelike
phenomena at multiple spatial and temporal scales. There are already several excellent …
phenomena at multiple spatial and temporal scales. There are already several excellent …
Mechanochemical regulation of growth cone motility
PC Kerstein, RH Nichol IV, TM Gomez - Frontiers in cellular …, 2015 - frontiersin.org
Neuronal growth cones are exquisite sensory-motor machines capable of transducing
features contacted in their local extracellular environment into guided process extension …
features contacted in their local extracellular environment into guided process extension …
Breakthroughs in the genetics of orofacial clefting
E Mangold, KU Ludwig, MM Nöthen - Trends in molecular medicine, 2011 - cell.com
Nonsyndromic orofacial clefts have a multifactorial etiology, involving both genetic and
environmental factors. Although linkage and candidate gene studies have attempted to …
environmental factors. Although linkage and candidate gene studies have attempted to …
Establishing neuronal polarity with environmental and intrinsic mechanisms
S Yogev, K Shen - Neuron, 2017 - cell.com
Neurons are among the most morphologically complex cells. A distinction between two
compartments, axon and dendrite, generates cellular domains that differ in membrane …
compartments, axon and dendrite, generates cellular domains that differ in membrane …