The trip of the tip: understanding the growth cone machinery

LA Lowery, DV Vactor - Nature reviews Molecular cell biology, 2009 - nature.com
The central component in the road trip of axon guidance is the growth cone, a dynamic
structure that is located at the tip of the growing axon. During its journey, the growth cone …

[HTML][HTML] Biomechanical microenvironment in peripheral nerve regeneration: from pathophysiological understanding to tissue engineering development

L Kong, X Gao, Y Qian, W Sun, Z You, C Fan - Theranostics, 2022 - ncbi.nlm.nih.gov
Peripheral nerve injury (PNI) caused by trauma, chronic disease and other factors may lead
to partial or complete loss of sensory, motor and autonomic functions, as well as neuropathic …

An integrated cytoskeletal model of neurite outgrowth

KE Miller, DM Suter - Frontiers in cellular neuroscience, 2018 - frontiersin.org
Neurite outgrowth underlies the wiring of the nervous system during development and
regeneration. Despite a significant body of research, the underlying cytoskeletal mechanics …

Actin waves: origin of cell polarization and migration?

N Inagaki, H Katsuno - Trends in cell biology, 2017 - cell.com
Actin filaments and associated proteins undergo wave-like movement in various cell types.
Recent studies with cutting-edge analyses, including live-cell imaging, biophysical …

Integrating chemistry and mechanics: the forces driving axon growth

K Franze - Annual review of cell and developmental biology, 2020 - annualreviews.org
The brain is our most complex organ. During development, neurons extend axons, which
may grow over long distances along well-defined pathways to connect to distant targets. Our …

[HTML][HTML] Neuronal polarization: From spatiotemporal signaling to cytoskeletal dynamics

M Schelski, F Bradke - Molecular and Cellular Neuroscience, 2017 - Elsevier
Neuronal polarization establishes distinct molecular structures to generate a single axon
and multiple dendrites. Studies over the past years indicate that this efficient separation is …

Waves in neural media

PC Bressloff - Lecture notes on mathematical modelling in the life …, 2014 - Springer
This is a book on mathematical neuroscience, in which the unifying theme is wavelike
phenomena at multiple spatial and temporal scales. There are already several excellent …

Mechanochemical regulation of growth cone motility

PC Kerstein, RH Nichol IV, TM Gomez - Frontiers in cellular …, 2015 - frontiersin.org
Neuronal growth cones are exquisite sensory-motor machines capable of transducing
features contacted in their local extracellular environment into guided process extension …

Breakthroughs in the genetics of orofacial clefting

E Mangold, KU Ludwig, MM Nöthen - Trends in molecular medicine, 2011 - cell.com
Nonsyndromic orofacial clefts have a multifactorial etiology, involving both genetic and
environmental factors. Although linkage and candidate gene studies have attempted to …

Establishing neuronal polarity with environmental and intrinsic mechanisms

S Yogev, K Shen - Neuron, 2017 - cell.com
Neurons are among the most morphologically complex cells. A distinction between two
compartments, axon and dendrite, generates cellular domains that differ in membrane …