The human body is the residence of a large number of commensal (non-pathogenic) and
pathogenic microbial species that have co-evolved with the human genome, adaptive …

ABSTRACT The World Health Organization (WHO) has warned that our current arsenal of
antibiotics is not innovative enough to face impending infectious diseases, especially those …

Hay una amplia diversidad de familias y grupos de antimicrobianos de interés clínico. Los
mecanismos por los que los compuestos con actividad antibacteriana inhiben el crecimiento …

The use of boron in small-molecule pharmaceuticals is increasing. Boron's ubiquitous
occurrence in nature and the recent success of a boronic acid drug (Velcade®) in the clinic …

The discovery of novel antibiotic classes has not kept pace with the growing threat of
bacterial resistance. Antibiotic candidates that act at new targets or via distinct mechanisms …

Aminoacyl-tRNA synthetases (ARSs) are universal enzymes that catalyze the attachment of
amino acids to the 3′ ends of their cognate tRNAs. The resulting aminoacylated tRNAs are …

Aminoacyl-tRNA synthetases (aaRSs) catalyze the esterification of tRNA with a cognate
amino acid and are essential enzymes in all three kingdoms of life. Due to their important …

Aminoacyl-tRNA synthetases are central enzymes in protein translation, providing the
charged tRNAs needed for appropriate construction of peptide chains. These enzymes have …

Abstract Aminoacyl-tRNA synthetases (aaRSs), essential components of the protein
synthesizing machinery, have been often chosen for devising therapeutics against parasitic …

Increasing resistance to antibiotics is a major problem worldwide and provides the stimulus
for development of new bacterial inhibitors with preferably different modes of action. In …