White adipose tissue (WAT) is an endocrine organ highly integrated in homeostasis and
capable of establishing ways of communicating and influencing multiple metabolic …

Irisin, out-membrane part of fibronectin type III domain–containing 5 protein (FNDC5), was
activated by Peroxisome proliferator-activated receptor γ (PPARγ) coactivator-1α (PGC-1α) …

Irisin, a novel hormone like polypeptide, is cleaved and secreted by an unknown protease
from a membrane‐spanning protein, FNDC5 (fibronectin type III domain‐containing protein …

Exercise not only produces beneficial effects on muscle itself via various molecular
pathways, but also mediates the interaction between muscles and other organs in an …

Context The risk of fragility fractures is increased in both type 1 and type 2 diabetes.
Numerous biochemical markers reflecting bone and/or glucose metabolism have been …

Inhibition of sclerostin is a therapeutic approach to lowering fracture risk in patients with
osteoporosis. However, data from phase 3 randomized controlled trials (RCTs) of …

Bone contributes to supporting the body, protecting the central nervous system and other
organs, hematopoiesis, the regulation of mineral metabolism (mainly calcium and …

This review covers the current knowledge on the regulation of the somatic growth axis and
its interaction with metabolism and feeding regulation. The main endocrine and …

Cardiovascular and metabolic diseases are the leading causes of death and disability
worldwide and impose a tremendous socioeconomic burden on individuals as well as the …

Herbal remedies have been used for centuries to ameliorate complications of diabetes
mellitus (DM). The aim of this study is to compare the effects of the oral curcumin supplement …