Cuproptosis is a novel type of copper-induced cell death that primarily occurs in cells that
utilize oxidative phosphorylation as the main metabolic pathway to produce energy. Copper …

Although the classic activities of p53 including induction of cell-cycle arrest, senescence,
and apoptosis are well accepted as critical barriers to cancer development, accumulating …

The function of p53 as a tumour suppressor has been attributed to its ability to promote cell
death or permanently inhibit cell proliferation. However, in recent years, it has become clear …

Apoptosis and necrosis are the two major modes of cell death, the molecular mechanisms of
which have been extensively studied. Although initially thought to constitute mutually …

Oxidative stress has long been implicated in cardiovascular disease, but more recently, the
role of reactive oxygen species (ROS) in normal physiological signaling has been …

Ischemia-associated oxidative damage leading to necrosis is a major cause of catastrophic
tissue loss, and elucidating its signaling mechanism is therefore of paramount importance …

Although metabolic alterations have been observed in cancer for almost a century, only
recently have the mechanisms underlying these changes been identified and the …

Multidomain pro-apoptotic BAX and BAK, once activated, permeabilize mitochondria to
trigger apoptosis, whereas anti-apoptotic BCL-2 members preserve mitochondrial integrity …

Apoptosis is a key mechanism for metazoans to eliminate unwanted cells. Resistance to
apoptosis is a hallmark of many cancer cells and a major roadblock to traditional …

Reactive oxygen species (ROS) play important roles in follicular development and survival.
Granulosa cell death is associated with increased ROS, but the mechanism of granulosa cell …