The measurement of vascular function in isolated vessels has revealed important insights
into the structural, functional, and biomechanical features of the normal and diseased …

The cerebral hyperaemia is one of the fundamental mechanisms for the central nervous
system homeostasis. Due also to this mechanism, oxygen and nutrients are maintained in …

Maintenance of brain function depends on a constant blood supply. Deficits in cerebral
blood flow are linked to cognitive decline, and they have detrimental effects on the outcome …

The brain possesses two intricate mechanisms that fulfill its continuous metabolic needs:
cerebral autoregulation, which ensures constant cerebral blood flow over a wide range of …

The roles of choline and of choline-containing phospholipids (CCPLs) on the maintenance
and progress of neurovascular unit (NVU) integrity are analyzed. NVU is composed of …

Continuous cerebral blood flow is essential for neuronal survival, but whether vascular tone
influences resting neuronal function is not known. Using a multidisciplinary approach in both …

Arteriolar smooth muscle cells (SMCs) and capillary pericytes dynamically regulate blood
flow in the central nervous system in the face of fluctuating perfusion pressures. Pressure …

Cerebral small vessel disease (CSVD) poses a serious socio-economic burden due to its
high prevalence and severe impact on the quality of life of elderly patients. Pathological …

The functions of the human brain are metabolically expensive and reliant on coupling
between cerebral blood flow (CBF) and neural activity, yet how this coupling evolves over …

Astrocytes are the most common glial cells in the brain with fine processes and endfeet that
intimately contact both neuronal synapses and the cerebral vasculature. They play an …