RNA sequencing: advances, challenges and opportunities
F Ozsolak, PM Milos - Nature reviews genetics, 2011 - nature.com
In the few years since its initial application, massively parallel cDNA sequencing, or RNA-
seq, has allowed many advances in the characterization and quantification of …
seq, has allowed many advances in the characterization and quantification of …
RNA interference as a prospective tool for the control of human viral infections
A Levanova, MM Poranen - Frontiers in Microbiology, 2018 - frontiersin.org
RNA interference (RNAi), which is mediated by small interfering RNAs (siRNAs) derived
from viral genome or its replicative intermediates, is a natural antiviral defense in plants …
from viral genome or its replicative intermediates, is a natural antiviral defense in plants …
Localized reconstruction of subunits from electron cryomicroscopy images of macromolecular complexes
Electron cryomicroscopy can yield near-atomic resolution structures of highly ordered
macromolecular complexes. Often however some subunits bind in a flexible manner, have …
macromolecular complexes. Often however some subunits bind in a flexible manner, have …
A mechanism for initiating RNA-dependent RNA polymerization
In most RNA viruses, genome replication and transcription are catalysed by a viral RNA-
dependent RNA polymerase. Double-stranded RNA viruses perform these operations in a …
dependent RNA polymerase. Double-stranded RNA viruses perform these operations in a …
The RNA polymerase activity of SARS-coronavirus nsp12 is primer dependent
AJW Te Velthuis, JJ Arnold, CE Cameron… - Nucleic acids …, 2010 - academic.oup.com
An RNA-dependent RNA polymerase (RdRp) is the central catalytic subunit of the RNA-
synthesizing machinery of all positive-strand RNA viruses. Usually, RdRp domains are …
synthesizing machinery of all positive-strand RNA viruses. Usually, RdRp domains are …
qiRNA is a new type of small interfering RNA induced by DNA damage
HC Lee, SS Chang, S Choudhary, AP Aalto, M Maiti… - Nature, 2009 - nature.com
RNA interference pathways use small RNAs to mediate gene silencing in eukaryotes. In
addition to small interfering RNAs (siRNAs) and microRNAs, several types of endogenously …
addition to small interfering RNAs (siRNAs) and microRNAs, several types of endogenously …
Structural analysis of the hepatitis C virus RNA polymerase in complex with ribonucleotides
S Bressanelli, L Tomei, FA Rey… - Journal of virology, 2002 - Am Soc Microbiol
We report here the results of a systematic high-resolution X-ray crystallographic analysis of
complexes of the hepatitis C virus (HCV) RNA polymerase with ribonucleoside …
complexes of the hepatitis C virus (HCV) RNA polymerase with ribonucleoside …
Synthetic biology approach for plant protection using ds RNA
A Niehl, M Soininen, MM Poranen… - Plant biotechnology …, 2018 - Wiley Online Library
Pathogens induce severe damages on cultivated plants and represent a serious threat to
global food security. Emerging strategies for crop protection involve the external treatment of …
global food security. Emerging strategies for crop protection involve the external treatment of …
Exogenous application of double-stranded RNA molecules from TMV p126 and CP genes confers resistance against TMV in tobacco
NC Konakalla, A Kaldis, M Berbati, H Masarapu… - Planta, 2016 - Springer
Main conclusion External application of dsRNA molecules from Tobacco mosaic virus (TMV)
p126 and CP genes confers significant resistance against TMV infection. Exogenously …
p126 and CP genes confers significant resistance against TMV infection. Exogenously …
De novo initiation of viral RNA-dependent RNA synthesis
CC Kao, P Singh, DJ Ecker - Virology, 2001 - Elsevier
RNA viruses use several initiation strategies to ensure that their RNAs are synthesized in
appropriate amounts, have correct termini, and can be translated efficiently. Many viruses …
appropriate amounts, have correct termini, and can be translated efficiently. Many viruses …