In the few years since its initial application, massively parallel cDNA sequencing, or RNA-
seq, has allowed many advances in the characterization and quantification of …

RNA interference (RNAi), which is mediated by small interfering RNAs (siRNAs) derived
from viral genome or its replicative intermediates, is a natural antiviral defense in plants …

Electron cryomicroscopy can yield near-atomic resolution structures of highly ordered
macromolecular complexes. Often however some subunits bind in a flexible manner, have …

In most RNA viruses, genome replication and transcription are catalysed by a viral RNA-
dependent RNA polymerase. Double-stranded RNA viruses perform these operations in a …

An RNA-dependent RNA polymerase (RdRp) is the central catalytic subunit of the RNA-
synthesizing machinery of all positive-strand RNA viruses. Usually, RdRp domains are …

RNA interference pathways use small RNAs to mediate gene silencing in eukaryotes. In
addition to small interfering RNAs (siRNAs) and microRNAs, several types of endogenously …

We report here the results of a systematic high-resolution X-ray crystallographic analysis of
complexes of the hepatitis C virus (HCV) RNA polymerase with ribonucleoside …

Pathogens induce severe damages on cultivated plants and represent a serious threat to
global food security. Emerging strategies for crop protection involve the external treatment of …

Main conclusion External application of dsRNA molecules from Tobacco mosaic virus (TMV)
p126 and CP genes confers significant resistance against TMV infection. Exogenously …

RNA viruses use several initiation strategies to ensure that their RNAs are synthesized in
appropriate amounts, have correct termini, and can be translated efficiently. Many viruses …