Reprogrammed metabolism is a hallmark of cancer. However, the metabolic dependency of
cancer, from tumour initiation through disease progression and therapy resistance, requires …

Triple negative breast cancer (TNBC), which is typically lack of expression of estrogen
receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 …

Obesity is a major driver of cancer, especially hepatocellular carcinoma (HCC). The
prevailing view is that non-alcoholic steatohepatitis (NASH) and fibrosis or cirrhosis are …

Signal transducer and activator of transcription 3 (STAT3) is constitutively activated in
numerous cancer types, including more than 40% of breast cancers. In contrast to tight …

Triple-negative breast cancers (TNBCs) constitute a heterogeneous subtype of breast
cancers that have a poor clinical outcome. Although no approved targeted therapy is …

Breast cancer (BC) is a serious worldwide disease that threatens women's health.
Particularly, the morbidity of triple-negative breast cancer (TNBC) is higher than that of other …

The signal transducer and activator of transcription 3 (STAT3) protein is a major transcription
factor involved in many cellular processes, such as cell growth and proliferation …

Although adoptive T‐cell therapy has shown remarkable clinical efficacy in haematological
malignancies, its success in combating solid tumours has been limited. Here, we report that …

The tumor-suppressor PTPN2 is diminished in a subset of triple-negative breast cancers
(TNBCs). Paradoxically, PTPN2-deficiency in tumors or T cells in mice can facilitate T cell …

Inflammation is at the forefront of carcinogenesis, tumor progression and resistance to
therapy. The Janus kinase (JAK)/signal transducer and activator of transcription (STAT) …