During nervous system development, neurons extend axons to reach their targets and form
functional circuits. The faulty assembly or disintegration of such circuits results in disorders …

The corpus callosum is the largest fibre tract in the brain, connecting the two cerebral
hemispheres, and thereby facilitating the integration of motor and sensory information from …

The chromatin-remodeling protein Satb2 plays a role in the generation of distinct subtypes of
neocortical pyramidal neurons. Previous studies have shown that Satb2 is required for …

The corpus callosum (CC) connects the cerebral hemispheres and is the major mammalian
commissural tract. It facilitates bilateral sensory integration and higher cognitive functions …

Brain malformations involving the corpus callosum are common in children with
developmental disabilities. We identified DCC mutations in four families and five sporadic …

Abstract Background Oxidation Resistance 1 (OXR1) gene is a highly conserved gene of the
TLDc domain-containing family. OXR1 is involved in fundamental biological and cellular …

Neuronal growth cone filopodia contain guidance receptors and contribute to axon
guidance; however, the mechanism by which the guidance cue netrin increases filopodia …

In this review we discuss recent advances in the understanding of the development of
forebrain projections attending to their origin, fate determination, and axon guidance. Major …

Of all brain regions, the 6-layered neocortex has undergone the most dramatic changes in
size and complexity during mammalian brain evolution. These changes, occurring in the …

Background Guidance molecules are normally presented to cells in an overlapping fashion;
however, little is known about how their signals are integrated to control the formation of …