The prevalence of obesity and diabetes mellitus (DM) has been consistently increasing
worldwide. Sharing powerful genetic and environmental features in their pathogenesis …

The cause of insulin resistance in obesity and type 2 diabetes mellitus (T2DM) is not limited
to impaired insulin signalling but also involves the complex interplay of multiple metabolic …

Although ample evidence links hepatic lipid accumulation with hepatic insulin resistance,
the mechanistic basis of this association is incompletely understood and controversial …

Ceramides are a heterogeneous group of bioactive membrane sphingolipids that play
specialized regulatory roles in cellular metabolism depending on their characteristic fatty …

Objective Ectopic fat deposition is associated with increased tissue production of ceramides.
Recent genetic mouse studies suggest that specific sphingolipid C16: 0 ceramide produced …

The mechanisms by which exercise benefits patients with non-alcoholic fatty liver disease
(NAFLD), the most common liver disease worldwide, remain poorly understood. A non …

Ceramide accumulation is a hallmark in the manifestation of numerous obesity-related
diseases, such as type 2 diabetes mellitus and atherosclerosis. Until the early 2000s …

Given the high and increasing prevalence of obesity, the safe and effective treatment of
obesity would be beneficial. Here, we examined whether oral hydroxysafflor yellow A …

Non-alcoholic fatty liver disease is one of the most common chronic liver diseases, ranging
from simple steatosis to steatohepatitis, fibrosis, and cirrhosis. Its prevalence is rapidly …

Specific forms of the lipid ceramide, synthesized by the ceramide synthase enzyme family,
are believed to regulate metabolic physiology. Genetic mouse models have established C16 …