Tandem repeat diseases include the neurodegenerative disorders known as polyglutamine
(polyQ) diseases, caused by CAG repeat expansions in the coding regions of the respective …

Post-translational modifications such as ubiquitination play important regulatory roles in
several biological processes in eukaryotes. This process could be reversed by …

With molecular treatments coming into reach for spinocerebellar ataxia type 3 (SCA 3),
easily accessible, cross‐species validated biomarkers for human and preclinical trials are …

The AAA+ ATPase valosin containing protein (VCP) is essential for cell and organ
homeostasis, especially in cells of the nervous system. As part of a large network, VCP …

Parkinson's disease (PD) is a common neurodegenerative disease that is mainly in middle-
aged people and elderly people, and the pathogenesis of PD is complex and diverse. The …

Alternative splicing significantly expands biological complexity, particularly in the vertebrate
nervous system. Increasing evidence indicates that developmental and tissue-dependent …

Spinocerebellar ataxia type 3 is the most common autosomal dominant inherited ataxia
worldwide, caused by a CAG repeat expansion in the Ataxin-3 gene resulting in a …

The presence and aggregation of misfolded proteins has deleterious effects in the nervous
system. Among the various diseases caused by misfolded proteins is the family of the …

Spinocerebellar ataxia type 3 (SCA3), caused by a CAG repeat expansion in the ataxin-3
gene (ATXN3), is characterized by neuronal polyglutamine (polyQ) ATXN3 protein …

The pathology of spinocerebellar ataxia type 3, also known as Machado‐Joseph disease, is
triggered by aggregation of toxic ataxin‐3 (ATXN3) variants containing expanded …