Hybrid Small-Molecule/Protein Fluorescent Probes

M Minoshima, SI Reja, R Hashimoto, K Iijima… - Chemical …, 2024 - ACS Publications
Hybrid small-molecule/protein fluorescent probes are powerful tools for visualizing protein
localization and function in living cells. These hybrid probes are constructed by diverse site …

Bringing together the best of chemistry and biology: hybrid indicators for imaging neuronal membrane potential

S Liu, J Yang, P Zou - Journal of Neuroscience Methods, 2021 - Elsevier
Membrane potential is an indispensable biophysical signal in neurobiology. Imaging
neuronal electrical signals with fluorescent indicators allows for non-invasive recording at …

Extended voltage imaging in cardiomyocytes with a triplet state quencher-stabilized silicon rhodamine

KN Martinez, NC Gerstner, SJ Yang… - Bioorganic & Medicinal …, 2024 - Elsevier
Voltage imaging of cardiac electrophysiology with voltage-sensitive dyes has long been a
powerful complement to traditional methods like patch-clamp electrophysiology. Chemically …

Voltage Imaging in Drosophila Using a Hybrid Chemical-Genetic Rhodamine Voltage Reporter

MJ Kirk, BR Benlian, Y Han, A Gold, A Ravi… - Frontiers in …, 2021 - frontiersin.org
We combine a chemically-synthesized, voltage-sensitive fluorophore with a genetically
encoded, self-labeling enzyme to enable voltage imaging in Drosophila melanogaster …

Optical Estimation of Membrane Potential Values Using Fluorescence Lifetime Imaging Microscopy and Hybrid Chemical-Genetic Voltage Indicators

AMM Gest, V Grenier, EW Miller - Bioelectricity, 2024 - liebertpub.com
Introduction: Membrane potential (V m), the voltage across a cell membrane, is an important
biophysical phenomenon, central to the physiology of cells, tissues, and organisms. Voltage …

Optimization of the Procedure for Gram Scale Synthesis of Silicon Rhodamine and its Application in Labeling BRD4 Kinase Inhibitor

Y Zhou, T Bi, R Wang, P Liang, J Lai, Q Luo… - Journal of Analysis and …, 2024 - Springer
Due to its high photo‑stability and near‑infrared (NIR) emis‑sion, silicon rhodamine (SiR) has
achieved wide applications in visualization of small molecules and biomolecules in liv‑ing …

Leveraging Isotopologues as a general strategy to image neurotransmitters with vibrational microscopy

GF Dorlhiac, MP Landry, A Streets - arXiv preprint arXiv:2205.05798, 2022 - arxiv.org
Chemical neurotransmission is central to neurotypical brain function but also implicated in a
variety of psychiatric and neurodegenerative diseases. The release dynamics of …

Chemical Targeting of Rhodol Voltage-Sensitive Dyes to Dopaminergic Neurons

T Fiala, EV Mosharov, J Wang… - ACS chemical …, 2022 - ACS Publications
Optical imaging of changes in the membrane potential of living cells can be achieved by
means of fluorescent voltage-sensitive dyes (VSDs). A particularly challenging task is to …

Procedure Optimization for Gram Scale Synthesis of Silicon Rhodamine and its Use in Labeling of Protein Kinase Inhibitor

T Bi, Y Zhou, P Liang, J Lai, Q Luo, H Wang… - Available at SSRN … - papers.ssrn.com
Due to its high photo-stability and Near-Infrared (NIR) emission, silicon rhodamine (SiR) has
achieved wide applications in visualization of small molecules and biomolecules in living …