Insights from multi-omics integration in complex disease primary tissues
Genome-wide association studies (GWAS) have provided insights into the genetic basis of
complex diseases. In the next step, integrative multi-omics approaches can characterize …
complex diseases. In the next step, integrative multi-omics approaches can characterize …
Genetics of type 2 diabetes: implications from large-scale studies
N DeForest, AR Majithia - Current diabetes reports, 2022 - Springer
Abstract Purpose of Review Type 2 diabetes (T2D) is a multifactorial, heritable syndrome
characterized by dysregulated glucose homeostasis that results from impaired insulin …
characterized by dysregulated glucose homeostasis that results from impaired insulin …
Development and validation of a trans-ancestry polygenic risk score for type 2 diabetes in diverse populations
T Ge, MR Irvin, A Patki, V Srinivasasainagendra… - Genome Medicine, 2022 - Springer
Abstract Background Type 2 diabetes (T2D) is a worldwide scourge caused by both genetic
and environmental risk factors that disproportionately afflicts communities of color …
and environmental risk factors that disproportionately afflicts communities of color …
Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program
One of the justifiable criticisms of human genetic studies is the underrepresentation of
participants from diverse populations. Lack of inclusion must be addressed at-scale to …
participants from diverse populations. Lack of inclusion must be addressed at-scale to …
Genome-wide risk prediction of common diseases across ancestries in one million people
Polygenic risk scores (PRS) measure genetic disease susceptibility by combining risk effects
across the genome. For coronary artery disease (CAD), type 2 diabetes (T2D), and breast …
across the genome. For coronary artery disease (CAD), type 2 diabetes (T2D), and breast …
[HTML][HTML] The whole pomegranate (Punica granatum. L), biological properties and important findings: A review
AG Valero-Mendoza, NP Meléndez-Rentería… - Food Chemistry …, 2023 - Elsevier
Abstract Background Pomegranate (Punica granatum L.) is a fruit native to South Asia, and
currently can grown in tropical and subtropical areas, including Mexico, which produces …
currently can grown in tropical and subtropical areas, including Mexico, which produces …
Polygonatum sibiricum saponin Exerts Beneficial Hypoglycemic Effects in Type 2 Diabetes Mice by Improving Hepatic Insulin Resistance and Glycogen Synthesis …
Z Chen, J Luo, M Jia, Y Chai, Y Bao - Nutrients, 2022 - mdpi.com
Type 2 diabetes mellitus (T2DM) is a systemic metabolic disorder characterized by insulin
deficiency and insulin resistance. Recently, it has become a significant threat to public …
deficiency and insulin resistance. Recently, it has become a significant threat to public …
Epidemiology of diabetes and atherosclerotic cardiovascular disease among Asian American adults: implications, management, and future directions: a scientific …
Asian American individuals make up the fastest growing racial and ethnic group in the
United States. Despite the substantial variability that exists in type 2 diabetes and …
United States. Despite the substantial variability that exists in type 2 diabetes and …
A population-specific reference panel for improved genotype imputation in African Americans
There is currently a dearth of accessible whole genome sequencing (WGS) data for
individuals residing in the Americas with Sub-Saharan African ancestry. We generated …
individuals residing in the Americas with Sub-Saharan African ancestry. We generated …
Therapeutic potential of non-starch polysaccharides on type 2 diabetes: From hypoglycemic mechanism to clinical trials
M Xiao, X Jia, N Wang, J Kang, X Hu… - Critical Reviews in …, 2024 - Taylor & Francis
Non-starch polysaccharides (NSPs) have been reported to exert therapeutic potential on
managing type 2 diabetes mellitus (T2DM). Various mechanisms have been proposed; …
managing type 2 diabetes mellitus (T2DM). Various mechanisms have been proposed; …