Neurons of the mammalian central nervous system fail to regenerate. Substantial progress
has been made toward identifying the cellular and molecular mechanisms that underlie …

Spinal cord injury (SCI) leads to loss of motor and sensory function below the injury level
and imposes a considerable burden on patients, families, and society. Repair of the injured …

Since no approved therapies to restore mobility and sensation following spinal cord injury
(SCI) currently exist, a better understanding of the cellular and molecular mechanisms …

Transected axons fail to regrow across anatomically complete spinal cord injuries (SCI) in
adults. Diverse molecules can partially facilitate or attenuate axon growth during …

Spinal cord injury (SCI) lesions present diverse challenges for repair strategies.
Anatomically complete injuries require restoration of neural connectivity across lesions …

A determinant of axon regeneration is the intrinsic growth ability of injured neurons, which
dictates a battery of injury responses in axons and cell bodies. While some of these …

The inability to recover functions lost after severe spinal cord injury has been recognized for
millennia and was first attributed to a failure of spinal cord neural regeneration over 100 …

Macropinocytosis is a unique pathway of endocytosis characterised by the nonspecific
internalisation of large amounts of extracellular fluid, solutes and membrane in large …

Astrocytes react to CNS injury by building a dense wall of filamentous processes around the
lesion. Stromal cells quickly take up residence in the lesion core and synthesize connective …

Contusive spinal cord injury leads to a variety of disabilities owing to limited neuronal
regeneration and functional plasticity. It is well established that an upregulation of glial …