Pulsatile desynchronizing delayed feedback for closed-loop deep brain stimulation

OV Popovych, B Lysyansky, M Rosenblum, A Pikovsky… - PloS one, 2017 - journals.plos.org
High-frequency (HF) deep brain stimulation (DBS) is the gold standard for the treatment of
medically refractory movement disorders like Parkinson's disease, essential tremor, and …

Robust desynchronization of Parkinson's disease pathological oscillations by frequency modulation of delayed feedback deep brain stimulation

M Daneshzand, M Faezipour, BD Barkana - PloS one, 2018 - journals.plos.org
The hyperkinetic symptoms of Parkinson's Disease (PD) are associated with the ensembles
of interacting oscillators that cause excess or abnormal synchronous behavior within the …

Model-based optimized phase-deviation deep brain stimulation for Parkinson's disease

Y Yu, Y Hao, Q Wang - Neural networks, 2020 - Elsevier
High-frequency deep brain stimulation (HF-DBS) of the subthalamic nucleus (STN), globus
pallidus interna (GPi) and globus pallidus externa (GPe) are often considered as effective …

Cortical information flow in Parkinson's disease: a composite network/field model

CC Kerr, SJ Van Albada, SA Neymotin… - Frontiers in …, 2013 - frontiersin.org
The basal ganglia play a crucial role in the execution of movements, as demonstrated by the
severe motor deficits that accompany Parkinson's disease (PD). Since motor commands …

Synchronized beta-band oscillations in a model of the globus pallidus-subthalamic nucleus network under external input

S Ahn, SE Zauber, RM Worth… - Frontiers in …, 2016 - frontiersin.org
Hypokinetic symptoms of Parkinson's disease are usually associated with excessively strong
oscillations and synchrony in the beta frequency band. The origin of this synchronized …

Optimal control of directional deep brain stimulation in the parkinsonian neuronal network

D Fan, Z Wang, Q Wang - … in Nonlinear Science and Numerical Simulation, 2016 - Elsevier
The effect of conventional deep brain stimulation (DBS) on debilitating symptoms of
Parkinson's disease can be limited because it can only yield the spherical field. And, some …

Application of neural networks in early detection and diagnosis of Parkinson's disease

RF Olanrewaju, NS Sahari, AA Musa… - … Conference on Cyber …, 2014 - ieeexplore.ieee.org
Parkinson's disease (PD) is a chronic neurological progressive disorder caused by lack of
the chemical dopamine in the brain. Up to today, there is still no cure or prevention for PD …

Disrupting abnormal neuronal oscillations with adaptive delayed feedback control

DL de Castro, M Aroso, AP Aguiar, DB Grayden… - Elife, 2024 - elifesciences.org
Closed-loop neuronal stimulation has a strong therapeutic potential for neurological
disorders such as Parkinson's disease. However, at the moment, standard stimulation …

Effects of electrical and optogenetic deep brain stimulation on synchronized oscillatory activity in parkinsonian basal ganglia

S Ratnadurai-Giridharan, CC Cheung… - … on Neural Systems …, 2017 - ieeexplore.ieee.org
Conventional deep brain stimulation of basal ganglia uses high-frequency regular electrical
pulses to treat Parkinsonian motor symptoms but has a series of limitations. Relatively new …

Improving desynchronization of parkinsonian neuronal network via triplet-structure coordinated reset stimulation

D Fan, Q Wang - Journal of theoretical biology, 2015 - Elsevier
We investigate how the triplet-structure coordinated reset stimulations (CRS), which acts on
the GPe, STN and GPi within the basal ganglia-thalamocortical motor circuit, can destabilize …