Solid-state NMR spectroscopy to probe state and phase transitions in frozen solutions
Freezing is commonly encountered during the processing and storage of biomacromolecule
products. Therefore, understanding the phase and state transitions in pharmaceutical frozen …
products. Therefore, understanding the phase and state transitions in pharmaceutical frozen …
Molecular Mechanisms for Stabilizing Biologics in the Solid State
Protein drugs exhibit challenges of biophysical and biochemical instability due to their
structural complexity and rich dynamics. Solid-state biologics aim to enhance stability by …
structural complexity and rich dynamics. Solid-state biologics aim to enhance stability by …
Investigation of Protein Therapeutics in Frozen Conditions Using DNP MAS NMR: A Study on Pembrolizumab
The success of modern biopharmaceutical products depends on enhancing the stability of
protein therapeutics. Freezing and thawing, which are common thermal stresses …
protein therapeutics. Freezing and thawing, which are common thermal stresses …
Probing Chemical Equilibrium in Frozen Sodium Phosphate Buffer Solution by 31P Solid-State NMR
Phosphate buffers are crucial for cryopreservative stability in pharmaceuticals, food
processing, biomedical sciences, and biology. However, their freeze concentrates lack …
processing, biomedical sciences, and biology. However, their freeze concentrates lack …