Lactic acid is one of the most abundant products of cellular metabolism and has historically
been considered a cell-damaging metabolic product. However, as research has deepened …

The Kingdom Plantae has provided several successful drugs for the treatment of different
diseases, including cancer, and continues to be a source of new possible therapeutic …

Cancer is one of the main causes of human mortality and brain tumors, including invasive
pituitary adenomas, medulloblastomas and glioblastomas are common brain malignancies …

Background Invasion and metastasis are determinant events in the prognosis of Colorectal
cancer (CRC), a common neoplasm worldwide. An important factor for metastasis is the …

Sufficient evidence has linked many different types of cancers and T2D through shared risk
factors; however, the underlying mechanisms are not fully understood. α-Hydroxybutyrate (α …

Colorectal cancer (CRC) is the third leading cause of cancer-related death worldwide in
both sexes. Current therapies include surgery, chemotherapy, and targeted therapy; …

Chemopreventive effects and associated mechanisms of withaferin A (WA) against intestinal
and colon carcinogenesis remain unknown. We investigated the chemopreventive effect of …

Inflammatory bowel disease (IBD) is a general term for a group of chronic and progressive
disorders. Several cellular and biomolecular pathways are implicated in the pathogenesis of …

Chemoresistance, which leads to the failure of chemotherapy and further tumor recurrence,
presents the largest hurdle for the success of anti-cancer therapy. In recent years, metformin …

Colorectal cancer (CRC) is among the top three most deadly cancers worldwide. The
survival rate for this disease has not been reduced despite the treatments, the reason why …