The MYC oncogene contributes to the genesis of many human cancers. Recent insights into
its expression and function have led to therapeutic opportunities. MYC's activation by …

Soon after the discovery of the Myc gene (c-Myc), it became clear that Myc expression levels
tightly correlate to cell proliferation. The entry in cell cycle of quiescent cells upon Myc …

Short tandem repeats (STRs) are enriched in eukaryotic cis-regulatory elements and alter
gene expression, yet how they regulate transcription remains unknown. We found that STRs …

Two opposing models have been proposed to describe the function of the MYC oncoprotein
in shaping cellular transcriptomes: one posits that MYC amplifies transcription at all active …

This review is intended to provide a broad outline of the biological and molecular functions
of MYC as well as of the larger protein network within which MYC operates. We present a …

Chromatin is important for the regulation of transcription and other functions, yet the diversity
of chromatin composition and the distribution along chromosomes are still poorly …

MYC regulates the transcription of thousands of genes required to coordinate a range of
cellular processes, including those essential for proliferation, growth, differentiation …

Just over 25 years ago, MYC, the human homologue of a retroviral oncogene, was
identified. Since that time, MYC research has been intense and the advances impressive …

We report the generation and analysis of functional data from multiple, diverse experiments
performed on a targeted 1% of the human genome as part of the pilot phase of the ENCODE …

Although cancers have altered glucose metabolism, termed the Warburg effect, which
describes the increased uptake and conversion of glucose to lactate by cancer cells under …