Developing skeletal muscles express unique myosin isoforms, including embryonic and
neonatal myosin heavy chains, coded by the myosin heavy chain 3 (MYH3) and MYH8 …

Mammalian skeletal muscle comprises different fiber types, whose identity is first established
during embryonic development by intrinsic myogenic control mechanisms and is later …

Skeletal muscle fibers are large syncytia but it is currently unknown whether gene
expression is coordinately regulated in their numerous nuclei. Here we show by snRNA-seq …

Skeletal muscle fibers differentiate into specific fiber types with distinct metabolic properties
determined by their reliance on oxidative phosphorylation (OXPHOS). Using in vivo …

Skeletal muscle is essential for mobility, stability and whole body metabolism, and muscle
loss, for instance, during sarcopenia, has profound consequences. Satellite cells (muscle …

Background Postnatal growth in mouse is rapid, with total skeletal muscle mass increasing
several-fold in the first few weeks. Muscle growth can be achieved by either an increase in …

MicroRNAs (miRNAs) are a class of highly conserved, noncoding RNAs involved in
posttranscriptional gene regulation. A small number of muscle-specific miRNAs have been …

The deteriorating in vivo environment is thought to play a major role in reduced stem cell
function with age. The capacity of stem cells to support tissue maintenance depends not only …

Muscle and its connective tissue are intimately linked in the embryo and in the adult,
suggesting that interactions between these tissues are crucial for their development …

Background: An in-depth understanding of the fundamental principles that regulate thyroid
hormone homeostasis is critical for the development of new diagnostic and treatment …