Multidrug resistance (MDR) is the dominant cause of the failure of cancer chemotherapy.
The design of antitumor drugs that are able to evade MDR is rapidly evolving, showing that …

We review the use of molecular dynamics (MD) simulation as a drug design tool in the
context of the role that the lipid membrane can play in drug action, ie, the interaction …

Isoniazid (INH) is one of the two most effective first-line antitubercular drugs and is still used
at the present time as a scaffold for developing new compounds to fight TB. In a previous …

Objectives Effective use of antibiotics is critical to control the global tuberculosis pandemic.
High-dose isoniazid (INH) can be effective in the presence of low-level resistance. We …

Membrane pan-assay interference compounds (PAINS) are a class of molecules that
interact nonspecifically with lipid bilayers and alter their physicochemical properties. An …

Prostate cancer (PCa) is the most frequent malignant cancer among men in the USA,
leading to substantial morbidity and mortality, while the existing treatments have restricted …

The chemical investigation of lichen Ramalina leiodea (Nyl.) Nyl. yielded five known
metabolites, ie., usnic acid (1), ethyl everninate (2), scrobiculin (3), methyl 2, 6-dihydroxy-4 …

The development of versatile antitumor agents with tumor-imaging, targeting and therapeutic
activity is promising for clinical cancer therapy. Prostate cancer is still the one of the leading …

Monoamine oxidase A (MAOA) is an important mitochondria-bound enzyme that catalyzes
the oxidative deamination of monoamine neurotransmitters. Accumulating evidence …

The growing incidence of skin cancer (SC) has prompted the search for additional
preventive strategies to counteract this global health concern. Mutant p53 (mutp53) …