Integrins mediate cell adhesion and transmit mechanical and chemical signals to the cell
interior. Various mechanisms deregulate integrin signaling in cancer, empowering tumor …

Human malignancies arise predominantly in tissues of epithelial origin, where the stepwise
transformation from healthy epithelium to premalignant dysplasia to invasive neoplasia …

Cancer is a group of cells that malignantly grow and proliferate uncontrollably. At present,
treatment modes for cancer mainly comprise surgery, chemotherapy, radiotherapy …

NF-κB comprises a family of five transcription factors that form distinct protein complexes,
which bind to consensus DNA sequences at promoter regions of responsive genes …

The nuclear factor‐κB (NF‐κB) transcription factor family has been considered the central
mediator of the inflammatory process and a key participant in innate and adaptive immune …

Inflammation is a fundamental protective response that sometimes goes awry and becomes
a major cofactor in the pathogenesis of many chronic human diseases, including cancer …

Cellular senescence acts as a potent barrier to tumorigenesis and contributes to the anti-
tumor activity of certain chemotherapeutic agents. Senescent cells undergo a stable cell …

The mediators and cellular effectors of inflammation are important constituents of the local
environment of tumours. In some types of cancer, inflammatory conditions are present before …

Significance: Extensive research during the last quarter century has revealed that reactive
oxygen species (ROS) produced in the body, primarily by the mitochondria, play a major role …

Activating mutations in KRAS occur in 30% to 40% of colorectal cancers. How mutant KRAS
alters cancer cell behavior has been studied intensively, but non-cell autonomous effects of …