Abstract Approximately 50% to 70% of all women with polycystic ovary syndrome (PCOS)
have some degree of insulin resistance, and this hormone insensitivity probably contributes …

Abstract Purpose of Review This perspective is motivated by the need to question dogma
that does not work: that the problem is insulin resistance (IR). We highlight the need to …

Type 2 diabetes is characterized by impaired insulin secretion. Some but not all studies
suggest that a decrease in β-cell mass contributes to this. We examined pancreatic tissue …

Adipose tissue expresses tumor necrosis factor (TNF) and interleukin (IL)-6, which may
cause obesity-related insulin resistance. We measured TNF and IL-6 expression in the …

Adiponectin is a 29-kDa adipocyte protein that has been linked to the insulin resistance of
obesity and lipodystrophy. To better understand the regulation of adiponectin expression …

OBJECTIVE—Available insulin sensitivity (IS) methods based on the oral glucose tolerance
test (OGTT) are empirical. We used a glucose-insulin model to derive an OGTT-based IS …

Leptin is an adipocyte-derived hormone that interacts with a putative receptor (s) in the
hypothalamus to regulate body weight. The relationship of leptin to metabolic abnormalities …

Nondiabetic obese humans adapt to insulin resistance by increasing β-cell mass. In
contrast, obese humans with type 2 diabetes have an∼ 60% deficit in β-cell mass. Recent …

Overweight and obesity are common findings in women of reproductive age in the UK; as
32% of 35‐to 64‐year‐old women are overweight and 21% obese. Obesity causes major …

OBJECTIVE Age-associated insulin resistance may underlie the higher prevalence of type 2
diabetes in older adults. We examined a corollary hypothesis that obesity and level of …