The uptake and metabolism of amino acids, and their unique role in the biology of pathogenic trypanosomatids
L Marchese, JF Nascimento, FS Damasceno… - Pathogens, 2018 - mdpi.com
Trypanosoma brucei, as well as Trypanosoma cruzi and more than 20 species of the genus
Leishmania, form a group of flagellated protists that threaten human health. These …
Leishmania, form a group of flagellated protists that threaten human health. These …
Computational approaches for drug discovery against trypanosomatid-caused diseases
CA Pereira, M Sayé, C Reigada, AM Silber… - Parasitology, 2020 - cambridge.org
During three decades, only about 20 new drugs have been developed for malaria,
tuberculosis and all neglected tropical diseases (NTDs). This critical situation was reached …
tuberculosis and all neglected tropical diseases (NTDs). This critical situation was reached …
Recent development in the uses of asparaginase as food enzyme
Abstract Asparaginase (EC 3.5. 1.1), an important enzyme, is broadly disseminated in all the
three domains of life and responsible for catalysing conversion of asparagine into aspartic …
three domains of life and responsible for catalysing conversion of asparagine into aspartic …
[PDF][PDF] Polypharmacological repurposing approach identifies approved drugs as potential inhibitors of Mycobacterium tuberculosis
Mycobacterium tuberculosis (M. tb), the causative pathogen of tuberculosis (TB) remains the
leading cause of death from single infectious agent. Furthermore, its evolution to multi-drug …
leading cause of death from single infectious agent. Furthermore, its evolution to multi-drug …
[HTML][HTML] L-Asparaginase of Leishmania donovani: Metabolic target and its role in Amphotericin B resistance
Abstract Emergence of Amphotericin B (AmB) resistant Leishmania donovani has posed
major therapeutic challenge against the parasite. Consequently, combination therapy aimed …
major therapeutic challenge against the parasite. Consequently, combination therapy aimed …
Antimicrobial‐resistant Neisseria gonorrhoeae can be targeted using inhibitors against evolutionary conservedl‐asparaginase
The emergence of multiple drug‐resistant “super gonorrhoea” complicates the management
and treatment of Neisseria gonorrhoeae infections due to the progressive accumulation of …
and treatment of Neisseria gonorrhoeae infections due to the progressive accumulation of …
Genomic Insight of Leishmania Parasite: In-Depth Review of Drug Resistance Mechanisms and Genetic Mutations
K Bharadava, TK Upadhyay, RS Kaushal, I Ahmad… - ACS …, 2024 - ACS Publications
Leishmaniasis, which is caused by a parasitic protozoan of the genus Leishmania, is still a
major threat to global health, impacting millions of individuals worldwide in endemic areas …
major threat to global health, impacting millions of individuals worldwide in endemic areas …
A quantum dot–MUC1 aptamer conjugate for targeted delivery of protoporphyrin IX and specific photokilling of cancer cells through ROS generation
Non-targeted photosensitizers lack selectivity that undermines the potential use of
photodynamic therapy (PDT). Herein, we report the DNA mediated assembly of a ZnSe/ZnS …
photodynamic therapy (PDT). Herein, we report the DNA mediated assembly of a ZnSe/ZnS …
HAT2 mediates histone H4K4 acetylation and affects micrococcal nuclease sensitivity of chromatin in Leishmania donovani
Histone post-translational modifications (PTMs) such as acetylation and methylation are
known to affect chromatin higher order structures. Primary targets of these modifications …
known to affect chromatin higher order structures. Primary targets of these modifications …
Systematic computational strategies for identifying protein targets and lead discovery
Computational algorithms and tools have retrenched the drug discovery and development
timeline. The applicability of computational approaches has gained immense relevance …
timeline. The applicability of computational approaches has gained immense relevance …