[HTML][HTML] Toward a global virus genomic surveillance network

V Hill, G Githinji, CBF Vogels, AI Bento, C Chaguza… - Cell Host & Microbe, 2023 - cell.com
The COVID-19 pandemic galvanized the field of virus genomic surveillance, demonstrating
its utility for public health. Now, we must harness the momentum that led to increased …

Progress and challenges in virus genomic epidemiology

V Hill, C Ruis, S Bajaj, OG Pybus, MUG Kraemer - Trends in Parasitology, 2021 - cell.com
Genomic epidemiology, which links pathogen genomes with associated metadata to
understand disease transmission, has become a key component of outbreak response …

Clade I mpox virus genomic diversity in the Democratic Republic of the Congo, 2018–2024: predominance of zoonotic transmission

E Kinganda-Lusamaki, A Amuri-Aziza… - Cell, 2024 - cell.com
Recent reports raise concerns on the changing epidemiology of mpox in the Democratic
Republic of the Congo (DRC). High-quality genomes were generated for 337 patients from …

Acute SARS-CoV-2 infections harbor limited within-host diversity and transmit via tight transmission bottlenecks

KM Braun, GK Moreno, C Wagner, MA Accola… - PLoS …, 2021 - journals.plos.org
The emergence of divergent SARS-CoV-2 lineages has raised concern that novel variants
eliciting immune escape or the ability to displace circulating lineages could emerge within …

Sensitive poliovirus detection using nested PCR and nanopore sequencing: A prospective validation study

AG Shaw, TK Mampuela, EL Lofiko, C Pratt… - Nature …, 2023 - nature.com
Timely detection of outbreaks is needed for poliovirus eradication, but gold standard
detection in the Democratic Republic of the Congo takes 30 days (median). Direct molecular …

A pan-African pathogen genomics data sharing platform to support disease outbreaks

A Christoffels, G Mboowa, P van Heusden… - Nature Medicine, 2023 - nature.com
A pan-African pathogen genomics data sharing platform to support disease outbreaks | Nature
Medicine Skip to main content Thank you for visiting nature.com. You are using a browser …

Approaches and challenges to inferring the geographical source of infectious disease outbreaks using genomic data

Z Chen, P Lemey, H Yu - The Lancet Microbe, 2024 - thelancet.com
Genomic data hold increasing potential in the elucidation of transmission dynamics and
geographical sources of infectious disease outbreaks. Phylogeographic methods that use …

[HTML][HTML] A review of broadly protective monoclonal antibodies to treat Ebola virus disease

P Rijal, FR Donnellan - Current Opinion in Virology, 2023 - Elsevier
Highlights•mAbs mixture targeting independent epitopes are better therapeutics.•Optimizing
antibody efficacy: in vitro maturation, afucosylation, Fc modifications.•Monitoring of natural …

The impact of sampling bias on viral phylogeographic reconstruction

P Liu, Y Song, C Colijn… - PLoS Global Public Health, 2022 - journals.plos.org
Genomic epidemiology plays an ever-increasing role in our understanding of and response
to the spread of infectious pathogens. Phylogeography, the reconstruction of the historical …

Filoviruses: scientific gaps and prototype pathogen recommendation

LC Dupuy, CF Spiropoulou, JS Towner… - The Journal of …, 2023 - academic.oup.com
Viruses in the family Filoviridae, including the commonly known Ebola (EBOV) and Marburg
(MARV) viruses, can cause severe hemorrhagic fever in humans and nonhuman primates …