Intellectual curiosity has always been one of the major driving forces leading to new
advances in chemistry. At the onset of the 20th century, the fact that biaryls could be optically …

Leishmaniasis, usually caused by the genus Leishmania, has not received the attention it
deserves and in recent times has developed into a major health problem worldwide. 1, 2 …

Covering: up to April 2021 During the past decades, a plethora of natural products with
restricted rotation about a biaryl axis have been discovered, among them the …

Nanoparticles may address challenges by human diseases through improving diagnosis,
vaccination and treatment. The uptake mechanism regulates the type of threat a particle …

Covering: up to April 2019 Dimeric naphthylisoquinoline (NIQ) alkaloids are an emerging
group of structurally, biosynthetically, and pharmacologically intriguing natural products, as …

By combining docking and molecular dynamics simulations, we explored a library of 65
mostly axially chiral naphthylisoquinoline alkaloids and their analogues, with most different …

A marine‐derived fungus of the genus Stachylidium was isolated from the sponge
Callyspongia cf. C. flammea. Chemical investigation of the bioactive fungal extract led to the …

Although miltefosine and paromomycin were registered as clinical agents against visceral
leishmaniasis in the last decade, the antileishmanial drug arsenal still requires …

This book describes a unique class of secondary metabolites, the mono-and dimeric
naphthylisoquinoline alkaloids. They occur in lianas of the paleotropical Ancistrocladaceae …

The N, C-coupled naphthyldihydroisoquinoline alkaloids ancistrocladinium A (3) and B (4),
which possess an unprecedented iminium-aryl axis and show high in vitro antileishmanial …