Midkine (MDK) growth factor: a key player in cancer progression and a promising therapeutic target
Midkine is a heparin-binding growth factor, originally reported as the product of a retinoic
acid-responsive gene during embryogenesis, but currently viewed as a multifaceted factor …
acid-responsive gene during embryogenesis, but currently viewed as a multifaceted factor …
Midkine and pleiotrophin: two related proteins involved in development, survival, inflammation and tumorigenesis
T Muramatsu - The Journal of Biochemistry, 2002 - academic.oup.com
Midkine (MK) and pleiotrophin (PTN) are low molecular weight proteins with closely related
structures. They are mainly composed of two domains held by disulfide bridges, and there …
structures. They are mainly composed of two domains held by disulfide bridges, and there …
miR-1289 and “Zipcode”-like sequence enrich mRNAs in microvesicles
Despite intensive studies, the molecular mechanisms by which the genetic materials are
uploaded into microvesicles (MVs) are still unknown. This is the first study describing a …
uploaded into microvesicles (MVs) are still unknown. This is the first study describing a …
Nucleolin expressed at the cell surface is a marker of endothelial cells in angiogenic blood vessels
S Christian, J Pilch, ME Akerman, K Porkka… - The Journal of cell …, 2003 - rupress.org
A tumor-homing peptide, F3, selectively binds to endothelial cells in tumor blood vessels
and to tumor cells. Here, we show that the cell surface molecule recognized by F3 is …
and to tumor cells. Here, we show that the cell surface molecule recognized by F3 is …
Midkine binds to anaplastic lymphoma kinase (ALK) and acts as a growth factor for different cell types
GE Stoica, A Kuo, C Powers, ET Bowden… - Journal of Biological …, 2002 - ASBMB
Midkine (MK) is a developmentally regulated, secreted growth factor homologous to
pleiotrophin (PTN). To investigate the potential role of MK in tumor growth, we expressed MK …
pleiotrophin (PTN). To investigate the potential role of MK in tumor growth, we expressed MK …
Pleiotrophin signals increased tyrosine phosphorylation of β-catenin through inactivation of the intrinsic catalytic activity of the receptor-type protein tyrosine …
K Meng, A Rodriguez-Pena… - Proceedings of the …, 2000 - National Acad Sciences
Pleiotrophin (PTN) is a platelet-derived growth factor-inducible, 18-kDa heparin-binding
cytokine that signals diverse phenotypes in normal and deregulated cellular growth and …
cytokine that signals diverse phenotypes in normal and deregulated cellular growth and …
Midkine and pleiotrophin in neural development and cancer
K Kadomatsu, T Muramatsu - Cancer letters, 2004 - Elsevier
The midkine (MK) family consists of only two members, namely heparin-binding growth
factors MK and pleiotrophin (PTN). During embryogenesis, MK is highly expressed in the …
factors MK and pleiotrophin (PTN). During embryogenesis, MK is highly expressed in the …
Tuning nanoparticle interactions with ovarian cancer through layer-by-layer modification of surface chemistry
Nanoparticle surface chemistry is a fundamental engineering parameter that governs tumor-
targeting activity. Electrostatic assembly generates controlled polyelectrolyte complexes …
targeting activity. Electrostatic assembly generates controlled polyelectrolyte complexes …
Midkine, a heparin-binding cytokine with multiple roles in development, repair and diseases
T Muramatsu - Proceedings of the Japan Academy, Series B, 2010 - jstage.jst.go.jp
Midkine is a heparin-binding cytokine or a growth factor with a molecular weight of 13 kDa.
Midkine binds to oversulfated structures in heparan sulfate and chondroitin sulfate. The …
Midkine binds to oversulfated structures in heparan sulfate and chondroitin sulfate. The …
An angiogenic role for the neurokines midkine and pleiotrophin in tumorigenesis
Recent analysis of bladder tumors has correlated expression of the neurokine midkine (MK)
with poor patient survival. To examine a role for MK and the related pleiotrophin (PTN) in …
with poor patient survival. To examine a role for MK and the related pleiotrophin (PTN) in …