Lipids represent the most abundant molecular type in the brain, with a fat content of∼ 60%
of the dry brain weight in humans. Despite this fact, little attention has been paid to …

Technological innovations have transformed the way scientists approach biological and
clinical questions, transiting from conventional ensemble assays in bulk to emphasize on the …

The lipidome is currently understudied but fundamental to life. Within the brain, little is
known about cell-type lipid heterogeneity, and even less is known about cell-to-cell lipid …

Each individual cell-type is defined by its distinct morphology, phenotype, molecular and
lipidomic profile. The importance of maintaining cell-specific lipidomic profiles is exemplified …

Lipids are major constituents of the brain largely implicated in physiological and
pathological processes. The hippocampus is a complex brain structure involved in learning …

Lipids are the most abundant but poorly explored components of the human brain. Here, we
present a lipidome map of the human brain comprising 75 regions, including 52 neocortical …

Lipids are essential cellular components forming membranes, serving as energy reserves,
and acting as chemical messengers. Dysfunction in lipid metabolism and signaling is …

Sphingolipids have been implicated in age-related neurodegeneration. Previous studies
have reported elevated ceramide levels in the brain of old rodents, but a systematic …

The recently unveiled extent of cellular heterogeneity demands for single-cell investigations
of intracellular metabolomes to reveal their roles in intracellular processes, molecular …

In Huntington's disease (HD), a key pathological feature includes the development of
inclusion-bodies of fragments of the mutant huntingtin protein in the neurons of the striatum …