Background Nonalcoholic fatty liver disease (NAFLD) comprises hepatic alterations with
increased lipid accumulation (steatosis) without or with inflammation (nonalcoholic …

Physical activity has been known as an essential element to promote human health for
centuries. Thus, exercise intervention is encouraged to battle against sedentary lifestyle …

Liver regeneration is a well-orchestrated process that is typically studied in animal models.
Although previous animal studies have offered many insights into liver regeneration, human …

A growing body of multiscale biomechanical studies has been proposed to highlight the
mechanical cues in the development of hepatic fibrosis and cancer. At the cellular level …

Reciprocal interactions between endothelial cells (ECs) and adipocytes are fundamental to
maintain white adipose tissue (WAT) homeostasis, as illustrated by the activation of …

Single-cell transcriptomics (scRNA-seq) has revolutionized the understanding of the spatial
architecture of tissue structure and function. Advancing the" transcript-centric" view of scRNA …

Metastasis is the primary cause of cancer-related mortality. Tumor cell interactions with cells
of the vessel wall are decisive and potentially rate-limiting for metastasis. The molecular …

Abstract 'Angiodiversity'refers to the structural and functional heterogeneity of endothelial
cells (EC) along the segments of the vascular tree and especially within the microvascular …

The tumor microenvironment (TME) is influenced by a" disorganized" extracellular matrix
(ECM) that sensitizes cancer cells toward mechanical stress, signaling, and structural …

Integrins are heterodimeric transmembrane receptors that connect the extracellular matrix
environment to the actin cytoskeleton via adaptor molecules through assembly of a range of …