[PDF][PDF] A systematic review on the synthesis and biological activity of hydrazide derivatives
MS Khan, SP Siddiqui, N Tarannum - Hygeia. J. Drugs Med, 2017 - hygeiajournal.com
Plan: A systematic review on the synthesis and biological activity of hydrazides and their
derivatives. Preface: The chemistry of hydrazide and its derivatives has obtained great …
derivatives. Preface: The chemistry of hydrazide and its derivatives has obtained great …
3 (2H)-pyridazinone derivatives: Synthesis, in-silico studies, structure-activity relationship and in-vitro evaluation for acetylcholinesterase enzyme inhibition
ÖF Çöl, İ Bozbey, B Türkmenoğlu, M Uysal - Journal of Molecular Structure, 2022 - Elsevier
New ten compounds bearing pyridazinone ring (5a–j) were designed and synthesized as
acetylcholinesterase inhibitors. The new derivatives were acquired via the reaction of …
acetylcholinesterase inhibitors. The new derivatives were acquired via the reaction of …
Discovery of novel 2, 6-disubstituted pyridazinone derivatives as acetylcholinesterase inhibitors
2, 6-Disubstituted pyridazinone 4 was identified by HTS as a novel acetylcholinesterase
(AChE) inhibitor. Under SAR development, compound 17e stood out as displaying high …
(AChE) inhibitor. Under SAR development, compound 17e stood out as displaying high …
A new series of pyridazinone derivatives as cholinesterases inhibitors: Synthesis, in vitro activity and molecular modeling studies
Background The pyridazinone nucleus has been incorporated into a wide variety of
therapeutically interesting molecules to transform them into better drugs …
therapeutically interesting molecules to transform them into better drugs …
Synthesis, Cytotoxicity and Anti-Proliferative Activity against AGS Cells of New 3(2H)-Pyridazinone Derivatives Endowed with a Piperazinyl Linker
Novel twenty-three 3 (2 H)-pyridazinone derivatives were designed and synthesized based
on the chemical requirements related to the anti-proliferative effects previously …
on the chemical requirements related to the anti-proliferative effects previously …
Drugs Against Neurodegenerative Diseases: Design and Synthesis of 6‐Amino–substituted Imidazo[1,2‐b]pyridazines as Acetylcholinesterase Inhibitors
P Sridhar, M Alagumuthu, B Ram, S Arumugam… - …, 2017 - Wiley Online Library
nitro‐6‐amino substituted–imidazo [1, 2‐b] pyridazine derivatives (5a–5 l) were synthesized
in four steps and characterized by FT‐IR, 1H NMR, 13C NMR and HRMS. 3‐nitro‐6‐amino …
in four steps and characterized by FT‐IR, 1H NMR, 13C NMR and HRMS. 3‐nitro‐6‐amino …
Synthesis, biological evaluation and molecular modeling studies of phthalazin-1 (2 H)-one derivatives as novel cholinesterase inhibitors
A new series of donepezil analogues based on the phthalazin-1 (2H)-one scaffold was
designed and synthesized with the aim of exploring its potential as human ChEIs. Biological …
designed and synthesized with the aim of exploring its potential as human ChEIs. Biological …
Synthesis, molecular modelling and biological activity of some pyridazinone derivatives as selective human monoamine oxidase-B inhibitors
Background Since brain neurotransmitter levels are associated with the pathology of various
neurodegenerative diseases like Parkinson and Alzheimer, monoamineoxidase (MAO) …
neurodegenerative diseases like Parkinson and Alzheimer, monoamineoxidase (MAO) …
Synthesis and biological evaluation of novel piperazine containing hydrazone derivatives
Some hydrazone derivatives were synthesized and their potential anticholinesterase
activities were examined. A series of eleven new compounds of N′‐(2, 4 …
activities were examined. A series of eleven new compounds of N′‐(2, 4 …
Design, synthesis, and molecular modeling of new 3(2H)-pyridazinone derivatives as acetylcholinesterase/butyrylcholinesterase inhibitors
Inhibition of cholinesterases is an effective method to curb Alzheimer's disease, a
progressive and fatal neurological disorder. A series of 6-substituted-3 (2 H)-pyridazinone-2 …
progressive and fatal neurological disorder. A series of 6-substituted-3 (2 H)-pyridazinone-2 …