Alzheimer's disease, a major and increasing global health challenge, is an irreversible,
progressive form of dementia, associated with an ongoing decline of brain functioning. The …

Dietary lipids are an indispensable source of energy and nutrition in human life. Numerous
studies have shown that dietary bioactive lipids have many health benefits, including …

The multifactorial nature of Alzheimer's disease (AD) is a reason for the lack of effective
drugs as well as a basis for the development of “multi-target-directed ligands”(MTDLs). As …

A combination of tacrine and tryptophan led to the development of a new family of
heterodimers as multi-target agents with potential to treat Alzheimer's disease. Based on the …

Introduction: To date, pharmacological treatment of Alzheimer's disease (AD) includes
Acetylcholinesterase Inhibitors (AChEIs) for mild-to-moderate AD, and memantine for …

Three new alkaloids, bersavine (3), muraricine (4), and berbostrejdine (8), together with
seven known isoquinoline alkaloids (1–2, 5–7, 9, and 10) were isolated from an alkaloidal …

Progressive cognitive decline in Alzheimer's disease (AD) is a growing challenge. Present
therapies are based on acetylcholinesterase inhibition providing only temporary relief …

Novel multifunctional tacrines for Alzheimer's disease were obtained by Ugi-reaction
between ferulic (or lipoic acid), a melatonin-like isocyanide, formaldehyde, and tacrine …

Inhibition of acetylcholinesterase (AChE) is a common treatment for early stages of the most
general form of dementia, Alzheimer's Disease (AD). In this study, methanol …

Quinoline analogs are an important class of N-based heterocyclic compounds, which have
received extensive attention because of their use in medicinal chemistry and organic …