Transcriptome and fatty-acid signatures of adipocyte hypertrophy and its non-invasive MR-based characterization in human adipose tissue

J Honecker, S Ruschke, C Seeliger, S Laber… - …, 2022 - thelancet.com
Background The adipocyte-hypertrophy associated remodeling of fat cell function is
considered causal for the development of metabolic disorders. A better understanding of …

Magnetic resonance imaging techniques for brown adipose tissue detection

M Wu, D Junker, RT Branca… - Frontiers in …, 2020 - frontiersin.org
Magnetic resonance imaging (MRI) and magnetic resonance spectroscopy (MRS) methods
can non-invasively assess brown adipose tissue (BAT) structure and function. Recently, MRI …

Diffusion‐weighted MR spectroscopy: Consensus, recommendations, and resources from acquisition to modeling

C Ligneul, C Najac, A Döring… - Magnetic resonance …, 2024 - Wiley Online Library
Brain cell structure and function reflect neurodevelopment, plasticity, and aging; and
changes can help flag pathological processes such as neurodegeneration and …

Lipid droplet–size mapping in human adipose tissue using a clinical 3T system

D Weidlich, J Honecker, C Boehm… - Magnetic resonance …, 2021 - Wiley Online Library
Purpose To develop a methodology for probing lipid droplet sizes with a clinical system
based on a diffusion‐weighted stimulated echo–prepared turbo spin‐echo sequence and to …

Practical considerations of diffusion-weighted MRS with ultra-strong diffusion gradients

CW Davies-Jenkins, A Döring, F Fasano… - Frontiers in …, 2023 - frontiersin.org
Introduction Diffusion-weighted magnetic resonance spectroscopy (DW-MRS) offers
improved cellular specificity to microstructure—compared to water-based methods alone …

Multiparametric MR Investigation of Proteoglycan Diffusivity, T2 Relaxation, and Concentration in an Ex Vivo Model of Intervertebral Disc Degeneration

M Wang, A Tsang, V Tam, D Chan… - Journal of Magnetic …, 2020 - Wiley Online Library
Background Proteoglycan (PG) is a major component of the intervertebral disc extracellular
matrix (ECM) that acts to hydrate the disc nucleus. Early detection of PG degradation is …

Reduction of vibration‐induced signal loss by matching mechanical vibrational states: Application in high b‐value diffusion‐weighted MRS

D Weidlich, M Zamskiy, M Maeder… - Magnetic resonance …, 2020 - Wiley Online Library
Purpose Diffusion encoding gradients are known to yield vibrations of the typical clinical MR
scanner hardware with a frequency of 20 to 30 Hz, which may lead to signal loss in diffusion …

Evaluation of brown adipose tissue with intermolecular double‐quantum coherence magnetic resonance spectroscopy at 3.0 T

L Lin, Q Zhang, N Wang, K Jiang, Y Lin… - NMR in …, 2022 - Wiley Online Library
In the current study, we propose a single‐voxel (SV) magnetic resonance spectroscopy
(MRS) pulse sequence, based on intermolecular double‐quantum coherence (iDQC), for in …

Monitoring apoptosis in intact cells by high‐resolution magic angle spinning 1H NMR spectroscopy

M Wylot, DTE Whittaker, SAC Wren… - NMR in …, 2021 - Wiley Online Library
Apoptosis maintains an equilibrium between cell proliferation and cell death. Many
diseases, including cancer, develop because of defects in apoptosis. A known metabolic …

Functional metabolic phenotyping of human pancreatic ductal adenocarcinoma

I Heid, S Karakaya, C Münch, SS Lueong… - bioRxiv, 2021 - biorxiv.org
Abstract Pancreatic Ductal Adenocarcinoma (PDAC) lacks targeted treatment options.
Although subtypes with transcriptome-based distinct lineage and differentiation features …