Endometriosis is defined as the development of endometrial glands and stroma outside the
uterine cavity. Pathophysiology of this disease includes abnormal hormone profiles, cell …

Reproduction is a key biological function requiring a precise synchronization with annual
and daily cues to cope with environmental fluctuations. Therefore, humans and animals …

Ovarian damage and fertility impairment are major side effects of chemotherapy in pre-
menopausal cancer patients. Cisplatin is a widely used chemotherapeutic drug. The present …

Polycystic ovary syndrome (PCOS) is increasingly being characterized as an evolutionary
mismatch disorder that presents with a complex mixture of metabolic and endocrine …

Follicular fluid (FF) plays a vital role in the bidirectional communication between oocytes and
granulosa cells (GCs), regulating and promoting oocyte growth and development. This fluid …

Melatonin is a promising reagent that can improve assisted reproductive technology (ART)
outcomes in infertility patients. However, melatonin is not effective for all infertile patients …

Background Growth differentiation factor-11 (GDF-11) belongs to the transforming growth
factor-β (TGF-β) superfamily. To date, the expression of GDF-11 in the ovary and its role in …

Ovarian hyperstimulation syndrome (OHSS) is a life-threatening and potentially fatal
complication during in vitro fertilization treatment. The levels of transforming growth factor-β1 …

Abstract Estradiol (E2), one of the main steroid hormones secreted by the ovaries, plays an
important role in maintaining normal female reproductive function. Ovarian granulosa cells …

Abstract Rationale: Growth differentiation factor-8 (GDF-8), also known as myostatin,
belongs to the transforming growth factor-beta (TGF-β) superfamily. GDF-8 is expressed in …