RNA Interference (RNAi) Screening in Drosophila
In the last decade, RNA interference (RNAi), a cellular mechanism that uses RNA-guided
degradation of messenger RNA transcripts, has had an important impact on identifying and …
degradation of messenger RNA transcripts, has had an important impact on identifying and …
Studies of neurodegenerative diseases using Drosophila and the development of novel approaches for their analysis
The use of Drosophila in neurodegenerative disease research has contributed to the
identification of modifier genes for the pathology. The basis for neurodegenerative disease …
identification of modifier genes for the pathology. The basis for neurodegenerative disease …
Bassoon contributes to tau-seed propagation and neurotoxicity
Tau aggregation is a defining histopathological feature of Alzheimer's disease and other
tauopathies. However, the cellular mechanisms involved in tau propagation remain unclear …
tauopathies. However, the cellular mechanisms involved in tau propagation remain unclear …
Animal models of neurodegenerative disease: Recent advances in fly highlight innovative approaches to drug discovery
JA Tello, HE Williams, RM Eppler… - Frontiers in molecular …, 2022 - frontiersin.org
Neurodegenerative diseases represent a formidable challenge to global health. As
advances in other areas of medicine grant healthy living into later decades of life, aging …
advances in other areas of medicine grant healthy living into later decades of life, aging …
Lipid-mediated phase separation of AGO proteins on the ER controls nascent-peptide ubiquitination
AGO/miRNA-mediated gene silencing and ubiquitin-mediated protein quality control
represent two fundamental mechanisms that control proper gene expression. Here, we …
represent two fundamental mechanisms that control proper gene expression. Here, we …
Lactobacillus probiotics improved the gut microbiota profile of a Drosophila melanogaster Alzheimer's disease model and alleviated neurodegeneration in the eye
FHP Tan, G Liu, SYA Lau, MH Jaafar… - Beneficial …, 2020 - wageningenacademic.com
Alzheimer's disease (AD) is a progressive disease and one of the most common forms of
neurodegenerative disorders. Emerging evidence is supporting the use of various strategies …
neurodegenerative disorders. Emerging evidence is supporting the use of various strategies …
Stretch-activated ion channel TMEM63B associates with developmental and epileptic encephalopathies and progressive neurodegeneration
A Vetro, C Pelorosso, S Balestrini, A Masi… - The American Journal of …, 2023 - cell.com
By converting physical forces into electrical signals or triggering intracellular cascades,
stretch-activated ion channels allow the cell to respond to osmotic and mechanical stress …
stretch-activated ion channels allow the cell to respond to osmotic and mechanical stress …
Identification of genomic enhancers through spatial integration of single‐cell transcriptomics and epigenomics
C Bravo González‐Blas, XJ Quan… - Molecular systems …, 2020 - embopress.org
Single‐cell technologies allow measuring chromatin accessibility and gene expression in
each cell, but jointly utilizing both layers to map bona fide gene regulatory networks and …
each cell, but jointly utilizing both layers to map bona fide gene regulatory networks and …
Drosophila melanogaster “a potential model organism” for identification of pharmacological properties of plants/plant-derived components
Plants/plant-derived components have been used from ancient times to treat/cure several
human diseases. Plants and their parts possess several chemical components that play the …
human diseases. Plants and their parts possess several chemical components that play the …
OXR1 maintains the retromer to delay brain aging under dietary restriction
Dietary restriction (DR) delays aging, but the mechanism remains unclear. We identified
polymorphisms in mtd, the fly homolog of OXR1, which influenced lifespan and mtd …
polymorphisms in mtd, the fly homolog of OXR1, which influenced lifespan and mtd …