The development of animal embryos is initially directed by maternal gene products. Then,
during the maternal-to-zygotic transition (MZT), developmental control is handed to the …

Recent results indicate that many untranslating mRNAs in somatic eukaryotic cells assemble
into related mRNPs that accumulate in specific cytoplasmic foci referred to as P bodies …

Cytoplasmic RNA granules in germ cells (polar and germinal granules), somatic cells (stress
granules and processing bodies), and neurons (neuronal granules) have emerged as …

The nematode C. elegans is attracted to nutritious bacteria and is repelled by pathogens
and toxins. Here we show that RNAi and toxin-mediated disruption of core cellular activities …

Post-transcriptional processes have a central role in the regulation of eukaryotic gene
expression. Although it has been known for a long time that these processes are functionally …

“Germ granules” are cytoplasmic, nonmembrane-bound organelles unique to germline.
Germ granules share components with the P bodies and stress granules of somatic cells, but …

mRNA decapping is a critical step in eukaryotic cytoplasmic mRNA turnover. Cytoplasmic
mRNA decapping is catalyzed by Dcp2 in conjunction with its coactivator Dcp1 and is …

Oocytes and sperm are some of the most differentiated cells in our bodies, yet they generate
all cell types after fertilization. Accumulating evidence suggests that this extraordinary …

Local control of mRNA translation modulates neuronal development, synaptic plasticity, and
memory formation. A poorly understood aspect of this control is the role and composition of …

A universal feature of metazoan sexual development is the generation of oocyte P granules
that withhold certain mRNA species from translation to provide coding potential for proteins …