Chronic pain and its associated comorbidities are difficult to treat, even when the most
potent analgesic compounds are used. Thus, research on new strategies to effectively …

Osteoarthritis and its associated comorbidities are important clinical problems that have a
negative impact on the quality of life, and its treatment remains unresolved. We investigated …

The role of carbon monoxide (CO) has evolved albeit controversial disputes on its toxicity.
This biological gasotransmitter participates in the endogenous regulation of …

Neuropathic pain manifested with allodynia and hyperalgesia usually becomes a chronic
condition accompanied with mood disorders. Clinical therapies for neuropathic pain are still …

The activation of heme oxygenase 1 (HO-1)/carbon monoxide (CO) inhibits chronic
inflammatory pain, but its role in the central nervous system (CNS) is not entirely known. We …

Background: Therapies to treat chronic neuropathic pain and its associated comorbidities
are limited. Recent studies demonstrated that the administration of slow-releasing hydrogen …

Chronic pain caused by persistent inflammation is current in multiple diseases and has a
strong negative impact on society. It is commonly associated with several mental illnesses …

Recent studies demonstrate that 5-fluoro-2-oxindole inhibits neuropathic pain but the
antinociceptive actions of this drug and its effects on the plasticity, oxidative and …

Pain is a multifaceted and complex pathology that is a worldwide health problem not only
from the medical perspective but also from social and economic perspectives. Numerous …

The Special Issue,“Protective and Detrimental Role of Heme Oxygenase-1”, of the
International Journal of Molecular Sciences, includes original research papers and reviews …