A comprehensive review on factors influences biogenesis, functions, therapeutic and clinical implications of exosomes

S Gurunathan, MH Kang, JH Kim - International journal of …, 2021 - Taylor & Francis
Exosomes are nanoscale-sized membrane vesicles secreted by almost all cell types into the
extracellular environment upon fusion of multivesicular bodies and plasma membrane …

Roles of extracellular vesicles in the aging microenvironment and age‐related diseases

Y Yin, H Chen, Y Wang, L Zhang… - Journal of extracellular …, 2021 - Wiley Online Library
Cellular senescence is a persistently hypoproliferative state with diverse stressors in a
specific aging microenvironment. Senescent cells have a double‐edged sword effect: they …

[HTML][HTML] Mesenchymal stem cell-derived extracellular vesicles ameliorate Alzheimer's disease-like phenotypes in a preclinical mouse model

AS Cone, X Yuan, L Sun, LC Duke, MP Vreones… - Theranostics, 2021 - ncbi.nlm.nih.gov
Alzheimer's disease (AD) is an irreversible neurodegenerative disorder that affects more
than 44 million people worldwide. Despite the high disease burden, there is no effective …

[HTML][HTML] Extracellular vesicles as bioactive nanotherapeutics: an emerging paradigm for regenerative medicine

M Li, F Fang, M Sun, Y Zhang, M Hu, J Zhang - Theranostics, 2022 - ncbi.nlm.nih.gov
In recent decades, extracellular vesicles (EVs), as bioactive cell-secreted nanoparticles
which are involved in various physiological and pathological processes including cell …

[HTML][HTML] New strategies of neurodegenerative disease treatment with extracellular vesicles (EVs) derived from mesenchymal stem cells (MSCs)

CP Palanisamy, JJ Pei, P Alugoju, NVA Anthikapalli… - Theranostics, 2023 - ncbi.nlm.nih.gov
Neurodegenerative diseases are characterized by the progressive loss of neurons and
intricate interactions between different cell types within the affected regions. Reliable …

Extracellular vesicles for tissue repair and regeneration: Evidence, challenges and opportunities

A Nagelkerke, M Ojansivu, L van der Koog… - Advanced drug delivery …, 2021 - Elsevier
Extracellular vesicles (EVs) are biological nanoparticles naturally secreted by cells, acting
as delivery vehicles for molecular messages. During the last decade, EVs have been …

TNF-α and IFN-γ participate in improving the immunoregulatory capacity of mesenchymal stem/stromal cells: Importance of cell–cell contact and extracellular vesicles

L López-García, ME Castro-Manrreza - International journal of molecular …, 2021 - mdpi.com
Mesenchymal stem/stromal cells (MSCs) have an immunoregulatory capacity and have
been used in different clinical protocols requiring control of the immune response. However …

[HTML][HTML] Engineered mesenchymal stem cell-derived extracellular vesicles: a state-of-the-art multifunctional weapon against Alzheimer's disease

T Yin, Y Liu, W Ji, J Zhuang, X Chen, B Gong, J Chu… - Theranostics, 2023 - ncbi.nlm.nih.gov
With the increase of population aging, the number of Alzheimer's disease (AD) patients is
also increasing. According to current estimates, approximately 11% of people over 65 suffer …

The role of TNF-α in the fate regulation and functional reprogramming of mesenchymal stem cells in an inflammatory microenvironment

W Li, Q Liu, J Shi, X Xu, J Xu - Frontiers in Immunology, 2023 - frontiersin.org
Mesenchymal stem cells (MSCs) are pluripotent stem cells with multidirectional
differentiation potential and strong immunomodulatory capacity. MSCs have been widely …

Stem cell-derived exosomes: a new strategy of neurodegenerative disease treatment

N Fayazi, M Sheykhhasan, S Soleimani Asl… - Molecular …, 2021 - Springer
Short-term symptomatic treatment and dose-dependent side effects of pharmacological
treatment for neurodegenerative diseases have forced the medical community to seek an …