Chitosan oligosaccharide (COS): An overview

M Naveed, L Phil, M Sohail, M Hasnat… - International journal of …, 2019 - Elsevier
The frequently studied polysaccharide, chitosan oligosaccharide/chitooligosaccharide
(COS) is the major degradation product of chitosan/chitin via chemical hydrolysis or …

Preparation and biological activities of chitosan oligosaccharides

G Benchamas, G Huang, S Huang, H Huang - Trends in Food Science & …, 2021 - Elsevier
Abstract Background Chitosan oligosaccharides (COSs) are the degraded products
prepared from the deacetylation and depolymerization of chitin or chitosan using physical …

Multifaceted computational modeling in glycoscience

S Perez, O Makshakova - Chemical Reviews, 2022 - ACS Publications
Glycoscience assembles all the scientific disciplines involved in studying various molecules
and macromolecules containing carbohydrates and complex glycans. Such an ensemble …

The cryo-EM structure of the bd oxidase from M. tuberculosis reveals a unique structural framework and enables rational drug design to combat TB

S Safarian, HK Opel-Reading, D Wu… - Nature …, 2021 - nature.com
New drugs are urgently needed to combat the global TB epidemic. Targeting simultaneously
multiple respiratory enzyme complexes of Mycobacterium tuberculosis is regarded as one of …

The atomic structure of a eukaryotic oligosaccharyltransferase complex

L Bai, T Wang, G Zhao, A Kovach, H Li - Nature, 2018 - nature.com
N-glycosylation is a ubiquitous modification of eukaryotic secretory and membrane-bound
proteins; about 90% of glycoproteins are N-glycosylated. The reaction is catalysed by an …

[HTML][HTML] Chitooligosaccharide: An evaluation of physicochemical and biological properties with the proposition for determination of thermal degradation products

L Phil, M Naveed, IS Mohammad, L Bo, D Bin - Biomedicine & …, 2018 - Elsevier
Being the most versatile biopolymer, chitooligosaccharide/chitosan oligosaccharide (COS)
has been extensively studied for a range of exceptional biological activities and potential …

Inward-facing conformation of a multidrug resistance MATE family transporter

S Zakrzewska, AR Mehdipour… - Proceedings of the …, 2019 - National Acad Sciences
Multidrug and toxic compound extrusion (MATE) transporters mediate excretion of
xenobiotics and toxic metabolites, thereby conferring multidrug resistance in bacterial …

Structure of outward-facing PglK and molecular dynamics of lipid-linked oligosaccharide recognition and translocation

C Perez, AR Mehdipour, G Hummer, KP Locher - Structure, 2019 - cell.com
PglK is a lipid-linked oligosaccharide (LLO) flippase essential for asparagine-linked protein
glycosylation in Campylobacter jejuni. Previously we have proposed a non-alternating …

[HTML][HTML] Enzymatic trans-bilayer lipid transport: Mechanisms, efficiencies, slippage, and membrane curvature

S Shukla, T Baumgart - Biochimica et Biophysica Acta (BBA) …, 2021 - Elsevier
The eukaryotic plasma membrane's lipid composition is found to be ubiquitously asymmetric
comparing inner and outer leaflets. This membrane lipid asymmetry plays a crucial role in …

Probing key elements of teixobactin–lipid II interactions in membranes

PC Wen, JM Vanegas, SB Rempe, E Tajkhorshid - Chemical Science, 2018 - pubs.rsc.org
Teixobactin (Txb) is a recently discovered antibiotic against Gram-positive bacteria that
induces no detectable resistance. The bactericidal mechanism is believed to be the …