Shaping the Nrf2-ARE-related pathways in Alzheimer's and Parkinson's diseases

L Fão, SI Mota, AC Rego - Ageing Research Reviews, 2019 - Elsevier
A failure in redox homeostasis is a common hallmark of Alzheimer's Disease (AD) and
Parkinson's Disease (PD), two age-dependent neurodegenerative disorders (NDD), causing …

Pharmacological modulation of Nrf2/HO-1 signaling pathway as a therapeutic target of Parkinson's disease

Y Wang, L Gao, J Chen, Q Li, L Huo, Y Wang… - Frontiers in …, 2021 - frontiersin.org
Parkinson's disease (PD) is a complex neurodegenerative disorder featuring both motor and
nonmotor symptoms associated with a progressive loss of dopaminergic neurons in the …

Oxidative stress in Parkinson's disease: Potential benefits of antioxidant supplementation

S Percário, A da Silva Barbosa… - Oxidative medicine …, 2020 - Wiley Online Library
Parkinson's disease (PD) occurs in approximately 1% of the population over 65 years of age
and has become increasingly more common with advances in age. The number of …

Effects of food-derived bioactive peptides on cognitive deficits and memory decline in neurodegenerative diseases: A review

S Wang, D Sun-Waterhouse, GIN Waterhouse… - Trends in Food Science …, 2021 - Elsevier
Background Memory and cognitive impairments/disorders are the main clinical symptoms of
neurodegenerative diseases. The prevalence of such chronic conditions has increased over …

Therapeutic application of natural products: NAD+ metabolism as potential target

C Guo, Q Huang, Y Wang, Y Yao, J Li, J Chen, M Wu… - Phytomedicine, 2023 - Elsevier
Background Nicotinamide adenine dinucleotide (NAD+) metabolism is involved in the entire
physiopathological process and is critical to human health. Long-term imbalance in NAD+ …

Control of reactive oxygen species for the prevention of Parkinson's disease: the possible application of flavonoids

TY Kim, E Leem, JM Lee, SR Kim - Antioxidants, 2020 - mdpi.com
Oxidative stress reflects an imbalance between the production of reactive oxygen species
(ROS) and antioxidant defense systems, and it can be associated with the pathogenesis and …

[HTML][HTML] Oxyphylla A ameliorates cognitive deficits and alleviates neuropathology via the Akt-GSK3β and Nrf2-Keap1-HO-1 pathways in vitro and in vivo murine …

Y Bian, Y Chen, X Wang, G Cui, COL Ung, JH Lu… - Journal of Advanced …, 2021 - Elsevier
Introduction Alzheimer's disease (AD) is a progressive brain disorder, and one of the most
common causes of dementia and amnesia. Due to the complex pathogenesis of AD, the …

The principal molecular mechanisms behind the activation of Keap1/Nrf2/ARE pathway leading to neuroprotective action in Parkinson's disease

A Chakkittukandiyil, DV Sajini, A Karuppaiah… - Neurochemistry …, 2022 - Elsevier
Parkinson's disease (PD) is a progressive neurodegenerative disorder. PD is associated
with the loss of dopaminergic neurons in the substantia nigra pars compacta region of the …

Natural phytochemicals as novel therapeutic strategies to prevent and treat Parkinson's disease: current knowledge and future perspectives

R Balakrishnan, S Azam, DY Cho… - Oxidative Medicine …, 2021 - Wiley Online Library
Parkinson's disease (PD) is the second‐most common neurodegenerative chronic disease
affecting both cognitive performance and motor functions in aged people. Yet despite the …

Cannabidiol exerts protective effects in an in vitro model of Parkinson's disease activating AKT/mTOR pathway

A Gugliandolo, F Pollastro, P Bramanti, E Mazzon - Fitoterapia, 2020 - Elsevier
Parkinson's disease (PD) is a neurodegenerative disorder characterized by the
degeneration of the nigrostriatal dopaminergic pathway with loss of substantia nigra pars …