Practitioner's guide to latent class analysis: methodological considerations and common pitfalls
P Sinha, CS Calfee, KL Delucchi - Critical care medicine, 2021 - journals.lww.com
Latent class analysis is a probabilistic modeling algorithm that allows clustering of data and
statistical inference. There has been a recent upsurge in the application of latent class …
statistical inference. There has been a recent upsurge in the application of latent class …
Biological phenotyping in sepsis and acute respiratory distress syndrome
P Sinha, NJ Meyer, CS Calfee - Annual review of medicine, 2023 - annualreviews.org
Heterogeneity in sepsis and acute respiratory distress syndrome (ARDS) is increasingly
being recognized as one of the principal barriers to finding efficacious targeted therapies …
being recognized as one of the principal barriers to finding efficacious targeted therapies …
Prevalence of phenotypes of acute respiratory distress syndrome in critically ill patients with COVID-19: a prospective observational study
Background In acute respiratory distress syndrome (ARDS) unrelated to COVID-19, two
phenotypes, based on the severity of systemic inflammation (hyperinflammatory and …
phenotypes, based on the severity of systemic inflammation (hyperinflammatory and …
Latent class analysis reveals COVID-19–related acute respiratory distress syndrome subgroups with differential responses to corticosteroids
P Sinha, D Furfaro, MJ Cummings… - American journal of …, 2021 - atsjournals.org
Rationale: Two distinct subphenotypes have been identified in acute respiratory distress
syndrome (ARDS), but the presence of subgroups in ARDS associated with coronavirus …
syndrome (ARDS), but the presence of subgroups in ARDS associated with coronavirus …
Identifying molecular phenotypes in sepsis: an analysis of two prospective observational cohorts and secondary analysis of two randomised controlled trials
P Sinha, VE Kerchberger, A Willmore… - The Lancet …, 2023 - thelancet.com
Background In sepsis and acute respiratory distress syndrome (ARDS), heterogeneity has
contributed to difficulty identifying effective pharmacotherapies. In ARDS, two molecular …
contributed to difficulty identifying effective pharmacotherapies. In ARDS, two molecular …
Systemic and organ-specific immune-related manifestations of COVID-19
M Ramos-Casals, P Brito-Zerón… - Nature Reviews …, 2021 - nature.com
Immune-related manifestations are increasingly recognized conditions in patients with
COVID-19, with around 3,000 cases reported worldwide comprising more than 70 different …
COVID-19, with around 3,000 cases reported worldwide comprising more than 70 different …
An update on management of adult patients with acute respiratory distress syndrome: an official American Thoracic Society clinical practice guideline
Background: This document updates previously published Clinical Practice Guidelines for
the management of patients with acute respiratory distress syndrome (ARDS), incorporating …
the management of patients with acute respiratory distress syndrome (ARDS), incorporating …
Phenotypes and personalized medicine in the acute respiratory distress syndrome
MA Matthay, YM Arabi, ER Siegel, LB Ware… - Intensive care …, 2020 - Springer
Although the acute respiratory distress syndrome (ARDS) is well defined by the
development of acute hypoxemia, bilateral infiltrates and non-cardiogenic pulmonary …
development of acute hypoxemia, bilateral infiltrates and non-cardiogenic pulmonary …
The inflammasome in times of COVID-19
Coronaviruses (CoVs) are members of the genus Betacoronavirus and the Coronaviridiae
family responsible for infections such as severe acute respiratory syndrome (SARS), Middle …
family responsible for infections such as severe acute respiratory syndrome (SARS), Middle …
Machine learning classifier models can identify acute respiratory distress syndrome phenotypes using readily available clinical data
P Sinha, MM Churpek, CS Calfee - American journal of respiratory …, 2020 - atsjournals.org
Rationale: Two distinct phenotypes of acute respiratory distress syndrome (ARDS) with
differential clinical outcomes and responses to randomly assigned treatment have …
differential clinical outcomes and responses to randomly assigned treatment have …