Interleukin-33 (IL-33) is a nuclear-associated cytokine of the IL-1 family originally described
as a potent inducer of allergic type 2 immunity. IL-33 signals via the receptor ST2, which is …

Chemokines and cytokines are critical for initiating and coordinating the organized and
sequential recruitment and activation of cells into Mycobacterium tuberculosis-infected …

Cytotoxic T lymphocyte (CTL) responses against tumors are maintained by stem-like
memory cells that self-renew but also give rise to effector-like cells. The latter gradually lose …

Anti-PD-1 immune checkpoint blockers can induce sustained clinical responses in cancer
but how they function in vivo remains incompletely understood. Here, we combined intravital …

Tumour-associated macrophages are abundant in many cancers, and often display an
immune-suppressive M2-like phenotype that fosters tumour growth and promotes resistance …

Interferon-γ is key in limiting Mycobacterium tuberculosis infection. Here we show that
vaccination triggered an accelerated interferon-γ response by CD4+ T cells in the lung …

Microbial penetration of the intestinal epithelial barrier triggers inflammatory responses that
include induction of the bactericidal C-type lectin RegIIIγ. Systemic administration of …

Allergic and parasitic worm immunity is characterized by infiltration of tissues with interleukin
(IL)-4-and IL-13-expressing cells, including T-helper-2 cells, eosinophils and basophils …

Dendritic cells (DC) are professional antigen sensing and presenting cells that link innate
and adaptive immunity. Within the DC population multiple subpopulations exist, each …

Summary Dendritic cells (DCs), monocytes, and/or macrophages initiate host-protective
immune responses to intracellular pathogens in part through interleukin-12 (IL-12) …