The acute respiratory distress syndrome (ARDS) is a life-threatening lung condition resulting
from direct and indirect insults to the lung. It is characterized by disruption of the endothelial …

The ability of the lung to perform gas exchange is made possible in part by the effective
relationship between the alveolar epithelium and the endothelium of the pulmonary …

Previous observations made by our laboratory indicate that Bruton's tyrosine kinase (Btk)
may play an important role in the pathophysiology of local inflammation in acute lung injury …

Background Despite decades of extensive studies, the morbidity and mortality for acute lung
injury/acute respiratory distress syndrome (ALI/ARDS) remained high. Particularly …

We have previously reported that the 26-amino acid N-terminus stalk region of soluble Fas
ligand (sFasL), which is separate from its binding site, is required for its biological function …

Cytokines regulate many aspects of cell growth and differentiation and play pivotal roles in
the orchestration of immune defence against invading pathogens. Though 'self'proteins, they …

LPS has been recently shown to induce muscarinic acetylcholine 3 receptor (M 3 receptor)
expression and penehyclidine hydrochloride (PHC) is an anticholinergic drug which could …

Background Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are the
first steps in the development of multiple organ failure induced by sepsis. A systemic …

Background Exposure to mechanical ventilation enhances lung injury in response to various
stimuli, such as bacterial endotoxin (LPS). The Fas/FasL system is a receptor ligand system …

Transfusion-related acute lung injury (TRALI) has been the leading cause of transfusion-
associated death for nearly a decade. Recent TRALI mitigation strategies focused on …