The cytochrome P450 (CYP) enzyme family is the most important enzyme system catalyzing
the phase 1 metabolism of pharmaceuticals and other xenobiotics such as herbal remedies …

This review deals with the two major aspects to be considered in the context of meat-based
functional foods and human health. One involves the different strategies used to improve …

This chapter is an update of the data on substrates, reactions, inducers, and inhibitors of
human CYP enzymes published previously by Rendic and DiCarlo Citation 1a, Citation 1b …

Variability of drug metabolism, especially that of the most important phase I enzymes or
cytochrome P450 (CYP) enzymes, is an important complicating factor in many areas of …

Objective Although the human small intestine serves primarily as an absorptive organ for
nutrients and water, it also has the ability to metabolise drugs. Interest in the small intestine …

Numerous members of the cytochrome P450 (CYP) superfamily are induced after exposure
to a variety of xenobiotics in human liver. We have gained considerable mechanistic insights …

Human CYP1A2 is one of the major CYPs in human liver and metabolizes a number of
clinical drugs (eg, clozapine, tacrine, tizanidine, and theophylline; n> 110), a number of …

The cytochrome P450 enzyme CYP1A2 mediates the rate‐limiting step in the metabolism of
many drugs including theophylline, clozapine, and tacrine as well as in the bioactivation of …

We all respond differently to drugs. Personalised medicine aims to improve efficacy and
reduce side effects, and efforts are being made to understand the physiological differences …

Metabolic food-drug interactions occur when the consumption of a particular food modulates
the activity of a drug-metabolising enzyme system, resulting in an alteration of the …