Induced pluripotent stem cells (iPSCs)—roles in regenerative therapies, disease modelling and drug screening

MAM Aboul-Soud, AJ Alzahrani, A Mahmoud - Cells, 2021 - mdpi.com
The discovery of induced pluripotent stem cells (iPSCs) has made an invaluable contribution
to the field of regenerative medicine, paving way for identifying the true potential of human …

3D lung tissue models for studies on SARS-CoV-2 pathophysiology and therapeutics

R Plebani, H Bai, L Si, J Li, C Zhang… - International Journal of …, 2022 - mdpi.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), causing the coronavirus
disease 2019 (COVID-19), has provoked more than six million deaths worldwide and …

The transcriptome landscape of the in vitro human airway epithelium response to SARS-CoV-2

S Assou, E Ahmed, L Morichon, A Nasri… - International Journal of …, 2023 - mdpi.com
Airway–liquid interface cultures of primary epithelial cells and of induced pluripotent stem-
cell-derived airway epithelial cells (ALI and iALI, respectively) are physiologically relevant …

iPSC-derived airway epithelial cells: progress, promise, and challenges

F Yu, F Liu, X Liang, L Duan, Q Li, G Pan, C Ma… - Stem Cells, 2023 - academic.oup.com
Induced pluripotent stem cells (iPSCs) generated from somatic cell sources are pluripotent
and capable of indefinite expansion in vitro. They provide an unlimited source of cells that …

The interplay between the airway epithelium and tissue macrophages during the SARS-CoV-2 infection

E Barreto-Duran, A Szczepański… - Frontiers in …, 2022 - frontiersin.org
The first line of antiviral immune response in the lungs is secured by the innate immunity.
Several cell types take part in this process, but airway macrophages (AMs) are among the …

[HTML][HTML] Conjunctival epithelial cells resist productive SARS-CoV-2 infection

RM Jackson, CF Hatton, JS Spegarova, M Georgiou… - Stem Cell Reports, 2022 - cell.com
Conjunctival epithelial cells, which express viral-entry receptors angiotensin-converting
enzyme 2 (ACE2) and transmembrane protease serine type 2 (TMPRSS2), constitute the …

Human galectin-9 potently enhances SARS-CoV-2 replication and inflammation in airway epithelial cells

L Du, MS Bouzidi, A Gala, F Deiter… - Journal of Molecular …, 2023 - academic.oup.com
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has caused
a global economic and health crisis. Recently, plasma levels of galectin-9 (Gal-9), a β …

Conditional reprogrammed human limbal epithelial cell model for anti-SARS-CoV-2 drug screening

Y Xiao, L Wang, S Li, S Fang, F Luo, S Chen, X Zou… - Heliyon, 2024 - cell.com
To minimize the global pandemic COVID-19 spread, understanding the possible
transmission routes of SARS-CoV-2 and discovery of novel antiviral drugs are necessary …

Human airway lineages derived from pluripotent stem cells reveal the epithelial responses to SARS-CoV-2 infection

R Wang, AJ Hume, ML Beermann… - … of Physiology-Lung …, 2022 - journals.physiology.org
There is an urgent need to understand how SARS-CoV-2 infects the airway epithelium and
in a subset of individuals leads to severe illness or death. Induced pluripotent stem cells …

Evaluation of the impact of iPSC differentiation protocols on transcriptomic signatures

V Chandrasekaran, S Wellens, A Bourguignon… - Toxicology in Vitro, 2024 - Elsevier
Human induced pluripotent stem cells (iPSC) have the potential to produce desired target
cell types in vitro and allow for the high-throughput screening of drugs/chemicals at …