The hormone melatonin (5-methoxy-N-acetyltryptamine) is synthesized primarily in the
pineal gland and retina, and in several peripheral tissues and organs. In the circulation, the …

Melatonin MT1 and MT2 receptor ligands have been vigorously explored for the last 4
decades. Inspection of approximately 80 publications in the field revealed that most …

Numerous physiological functions of the pineal gland hormone melatonin are mediated via
activation of two G-protein-coupled receptors, MT1 and MT2. The melatonergic drugs on the …

To develop a new therapeutic agent for sleep disorders, we synthesized a novel series of
tricyclic indan derivatives and evaluated them for their binding affinity to melatonin receptors …

Melatonin is a natural hormone primarily released by the pineal gland that regulates the
sleep-wake cycles. The diverse biological applications of melatonin, together with the need …

In this review we summarized the actual clinical data for a cardioprotective therapeutic role
of melatonin, listed melatonin and its agonists in different stages of development, and …

Melatonin is a hormone exerting its multiple actions mainly through two G‐protein‐coupled
receptors MT1 and MT2. Exploring the physiological role of each of these subtypes requires …

The synthesis of several novel indole melatonin analogues substituted at the 2-position with
acylaminomethyl (8− 11), acylaminoethyl (5a− k), or acylaminopropyl (13) side chains is …

Molecular superposition models guided the design of novel melatonin receptor ligands
characterized by a 2-acylaminomethyltetrahydroquinoline scaffold. Starting from the …

Dysregulation of glycogen synthase kinase (GSK-3β) is implicated in the pathophysiology of
many diseases, including type-2 diabetes, stroke, Alzheimer's, and others. A multistage …